| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-03-25 |
| タイトル |
|
|
タイトル |
Glyburide inhibits the bone resorption induced by traumatic occlusion in rats. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Glyburide |
| キーワード |
|
|
主題 |
NLRP3 inhibitor |
| キーワード |
|
|
主題 |
NLRP3 |
| キーワード |
|
|
主題 |
Occlusal trauma |
| キーワード |
|
|
主題 |
IL-1β |
| キーワード |
|
|
言語 |
en |
|
主題 |
Glyburide |
| キーワード |
|
|
言語 |
en |
|
主題 |
NLRP3 inhibitor |
| キーワード |
|
|
言語 |
en |
|
主題 |
NLRP3 |
| キーワード |
|
|
言語 |
en |
|
主題 |
Occlusal trauma |
| キーワード |
|
|
言語 |
en |
|
主題 |
IL-1β |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Arita, Yoichi
Yoshinaga, Yasunori
Kaneko, Takashi
Kawahara, Yuri
Nakamura, Keiko
Ohgi, Kimiko
Arita, Seiichi
Ryu, Takanori
Takase, Minoru
Sakagami, Ryuji
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
To examine whether glyburide inhibits bone destruction caused by traumatic occlusion in a rat occlusal trauma model. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Excessive mechanical stress, such as traumatic occlusion, induces expression of IL-1β and may be involved in bone resorption. NLRP3 inflammasomes have been linked to IL-1β expression, but it is currently unclear whether glyburide, the inhibiter of NLRP3 inflammasome, suppresses occlusal trauma in rats. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Male SD rats aged 7 weeks were used. In the trauma group, the occlusal surface of the maxillary first right molar was raised by attaching a metal wire to apply occlusal trauma to the mandibular first right molar. In the trauma + glyburide group, the NLRP3 inhibitor glyburide was administered orally every 24 hours from 1 day before induction of occlusal trauma. Rats were euthanized after 5 or 10 days, and the maxillary first molars were harvested with the adjacent tissues for histopathological investigation. Immunohistochemical expression of IL-1β, NLRP3, and RANKL was also assessed. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
On day 5, bone resorption was significantly greater in the trauma group compared with the control group or the trauma + glyburide group, and there were significantly higher numbers of osteoclasts and cells positive for IL-1β, NLRP3, and RANKL in the trauma group. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
In this study, glyburide inhibits bone resorption by traumatic occlusion in rats. It suggests that the NLRP3/IL-1β pathway might be associated with bone resorption induced by traumatic occlusion. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2019年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2020-03-14 |
| 報告番号 |
|
|
学位授与番号 |
甲第313号 |
| 関連サイト |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/jre.12731 |
|
|
関連名称 |
Wiley |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第313号_論文(有田陽一) (750.3 kB)
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