{"created":"2023-05-15T09:58:11.077508+00:00","id":111,"links":{},"metadata":{"_buckets":{"deposit":"d990a626-a1b5-4228-8d6a-ea15974ff1ad"},"_deposit":{"created_by":15,"id":"111","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"111"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000111","sets":["1:23:25"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-14"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2019年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To examine whether glyburide inhibits bone destruction caused by traumatic occlusion in a rat occlusal trauma model.","subitem_description_type":"Abstract"},{"subitem_description":"Excessive mechanical stress, such as traumatic occlusion, induces expression of IL-1β and may be involved in bone resorption. NLRP3 inflammasomes have been linked to IL-1β expression, but it is currently unclear whether glyburide, the inhibiter of NLRP3 inflammasome, suppresses occlusal trauma in rats.","subitem_description_type":"Abstract"},{"subitem_description":"Male SD rats aged 7 weeks were used. In the trauma group, the occlusal surface of the maxillary first right molar was raised by attaching a metal wire to apply occlusal trauma to the mandibular first right molar. In the trauma + glyburide group, the NLRP3 inhibitor glyburide was administered orally every 24 hours from 1 day before induction of occlusal trauma. Rats were euthanized after 5 or 10 days, and the maxillary first molars were harvested with the adjacent tissues for histopathological investigation. Immunohistochemical expression of IL-1β, NLRP3, and RANKL was also assessed.","subitem_description_type":"Abstract"},{"subitem_description":"On day 5, bone resorption was significantly greater in the trauma group compared with the control group or the trauma + glyburide group, and there were significantly higher numbers of osteoclasts and cells positive for IL-1β, NLRP3, and RANKL in the trauma group.","subitem_description_type":"Abstract"},{"subitem_description":"In this study, glyburide inhibits bone resorption by traumatic occlusion in rats. It suggests that the NLRP3/IL-1β pathway might be associated with bone resorption induced by traumatic occlusion.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第313号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Wiley"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/jre.12731","subitem_relation_type_select":"DOI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Arita, Yoichi"}]},{"creatorNames":[{"creatorName":"Yoshinaga, Yasunori"}]},{"creatorNames":[{"creatorName":"Kaneko, Takashi"}]},{"creatorNames":[{"creatorName":"Kawahara, Yuri"}]},{"creatorNames":[{"creatorName":"Nakamura, Keiko"}]},{"creatorNames":[{"creatorName":"Ohgi, Kimiko"}]},{"creatorNames":[{"creatorName":"Arita, Seiichi"}]},{"creatorNames":[{"creatorName":"Ryu, Takanori"}]},{"creatorNames":[{"creatorName":"Takase, Minoru"}]},{"creatorNames":[{"creatorName":"Sakagami, Ryuji"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-14"}],"displaytype":"detail","filename":"甲第313号_論文(有田陽一).pdf","filesize":[{"value":"750.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第313号_論文(有田陽一)","url":"https://fdc.repo.nii.ac.jp/record/111/files/甲第313号_論文(有田陽一).pdf"},"version_id":"2e5444dc-9eb7-4b42-9bc5-3953ec8a8766"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-14"}],"displaytype":"detail","filename":"甲第313号_論文内容の要旨(有田陽一).pdf","filesize":[{"value":"131.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第313号_論文内容の要旨(有田陽一)","url":"https://fdc.repo.nii.ac.jp/record/111/files/甲第313号_論文内容の要旨(有田陽一).pdf"},"version_id":"4b6f9813-f3bb-4225-99ca-c5d1fb6a76ed"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-14"}],"displaytype":"detail","filename":"甲第313号_論文審査結果の要旨(有田陽一).pdf","filesize":[{"value":"208.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第313号_論文審査結果の要旨(有田陽一)","url":"https://fdc.repo.nii.ac.jp/record/111/files/甲第313号_論文審査結果の要旨(有田陽一).pdf"},"version_id":"2112d488-2b64-4686-ae21-4cfe76eda4b7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glyburide"},{"subitem_subject":"NLRP3 inhibitor"},{"subitem_subject":"NLRP3"},{"subitem_subject":"Occlusal trauma"},{"subitem_subject":"IL-1β"},{"subitem_subject":"Glyburide","subitem_subject_language":"en"},{"subitem_subject":"NLRP3 inhibitor","subitem_subject_language":"en"},{"subitem_subject":"NLRP3","subitem_subject_language":"en"},{"subitem_subject":"Occlusal trauma","subitem_subject_language":"en"},{"subitem_subject":"IL-1β","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Glyburide inhibits the bone resorption induced by traumatic occlusion in rats.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Glyburide inhibits the bone resorption induced by traumatic occlusion in rats.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["25"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-25"},"publish_date":"2020-03-25","publish_status":"0","recid":"111","relation_version_is_last":true,"title":["Glyburide inhibits the bone resorption induced by traumatic occlusion in rats."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T02:16:31.191827+00:00"}