@phdthesis{oai:fdc.repo.nii.ac.jp:00000111,
 author = {Arita, Yoichi and Yoshinaga, Yasunori and Kaneko, Takashi and Kawahara, Yuri and Nakamura, Keiko and Ohgi, Kimiko and Arita, Seiichi and Ryu, Takanori and Takase, Minoru and Sakagami, Ryuji},
 month = {2021-12-14, 2021-12-14, 2021-12-14},
 note = {2019年度, To examine whether glyburide inhibits bone destruction caused by traumatic occlusion in a rat occlusal trauma model., Excessive mechanical stress, such as traumatic occlusion, induces expression of IL-1β and may be involved in bone resorption. NLRP3 inflammasomes have been linked to IL-1β expression, but it is currently unclear whether glyburide, the inhibiter of NLRP3 inflammasome, suppresses occlusal trauma in rats., Male SD rats aged 7 weeks were used. In the trauma group, the occlusal surface of the maxillary first right molar was raised by attaching a metal wire to apply occlusal trauma to the mandibular first right molar. In the trauma + glyburide group, the NLRP3 inhibitor glyburide was administered orally every 24 hours from 1 day before induction of occlusal trauma. Rats were euthanized after 5 or 10 days, and the maxillary first molars were harvested with the adjacent tissues for histopathological investigation. Immunohistochemical expression of IL-1β, NLRP3, and RANKL was also assessed., On day 5, bone resorption was significantly greater in the trauma group compared with the control group or the trauma + glyburide group, and there were significantly higher numbers of osteoclasts and cells positive for IL-1β, NLRP3, and RANKL in the trauma group., In this study, glyburide inhibits bone resorption by traumatic occlusion in rats. It suggests that the NLRP3/IL-1β pathway might be associated with bone resorption induced by traumatic occlusion.},
 school = {福岡歯科大学},
 title = {Glyburide inhibits the bone resorption induced by traumatic occlusion in rats.},
 year = {}
}