| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2019-02-07 |
| タイトル |
|
|
タイトル |
CO₂ laser therapy accelerates the healing of ulcers in the oral mucosa by inducing the expressions of heat shock protein-70 and tenascin C. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
CO2 レーザー |
| キーワード |
|
|
主題 |
創傷治癒 |
| キーワード |
|
|
主題 |
テネイシンC |
| キーワード |
|
|
主題 |
ヒートショック蛋白70 |
| キーワード |
|
|
主題 |
温度 |
| キーワード |
|
|
言語 |
en |
|
主題 |
CO2 laser |
| キーワード |
|
|
言語 |
en |
|
主題 |
wound healing |
| キーワード |
|
|
言語 |
en |
|
主題 |
tenascin C |
| キーワード |
|
|
言語 |
en |
|
主題 |
heat shock protein-70 |
| キーワード |
|
|
言語 |
en |
|
主題 |
temperature |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Gang, Luo
Oka, Kyoko
Ohki, Shirabe
Rikitake, Mihoko
Itaya, Satoshi
Tamura, Shougo
Toda-Nakamura, Masako
Ogata, Kayoko
Kira-Tatsuoka, Michiko
Ozaki, Masao
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The treatment of ulceration or stomatitis with laser therapy is known to accelerate healing and relieve pain, but the underlying biological mechanism is not fully understood. The present study used a mouse model of ulceration to investigate the molecular mechanisms by which CO₂ laser therapy accelerated the wound healing process. An ulcer was experimentally created in the palatal mucosa of the mouse and irradiated with light from a CO₂ laser. Compared with controls (no irradiation), laser irradiation induced the proliferation of epithelial cells and faster re-epithelialization of the wound area. Immunohistochemistry experiments showed that heat shock protein-70 (HSP70) was expressed mainly in the epithelium of normal palatal tissue, whereas there was little tenascin C (TnC) expression in the epithelium and mesenchyme under normal conditions. Laser irradiation induced HSP70 mRNA and protein expression in the lamina propria as well as TnC expression in the mesenchyme underlying the renewing epithelium. Epithelial cells and fibroblasts were exposed to heated culture medium or laser irradiation to establish whether hyperthermia mimicked the effect of laser irradiation. Culture of fibroblasts in heated medium increased the expressions of both TnC and TGF-β1, whereas laser irradiation induced only TnC expression. The present study indicates that CO₂ laser irradiation exerts a photobiogenic effect to up-regulate TnC expression without inducing TGF-β1 expression. We suggest that CO₂ laser therapy has an advantage over thermal stimulation. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2018年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2018-09-27 |
| 報告番号 |
|
|
学位授与番号 |
甲第302号 |
| 関連サイト |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.14670/HH-18-037 |
|
|
関連名称 |
Histology and histopathology |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第302号_論文(LuoGang) (679.0 kB)
.png)
