{"_buckets": {"deposit": "8d4272ba-af55-4694-9b30-a913fd407721"}, "_deposit": {"created_by": 15, "id": "95", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "95"}, "status": "published"}, "_oai": {"id": "oai:fdc.repo.nii.ac.jp:00000095", "sets": ["19"]}, "author_link": [], "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2018-03-29"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与大学", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "福岡歯科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "37114"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（歯学）"}]}, "item_10006_description_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "2017年度"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step.", "subitem_description_type": "Abstract"}]}, "item_10006_dissertation_number_12": {"attribute_name": "報告番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第298号"}]}, "item_10006_relation_15": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "OXFORD"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1093/femsyr/foy018", "subitem_relation_type_select": "DOI"}}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sonoko, Tasaki"}]}, {"creatorNames": [{"creatorName": "Tamaki, Cho"}]}, {"creatorNames": [{"creatorName": "Jun-ichi, Nagao"}]}, {"creatorNames": [{"creatorName": "Shojiro, Ikezaki"}]}, {"creatorNames": [{"creatorName": "Yuka, Narita"}]}, {"creatorNames": [{"creatorName": "Ken-ichi, Arita-Morioka"}]}, {"creatorNames": [{"creatorName": "Kanae, Yasumatsu"}]}, {"creatorNames": [{"creatorName": "Keita, Toyoda"}]}, {"creatorNames": [{"creatorName": "Hiroshi, Kojima"}]}, {"creatorNames": [{"creatorName": "Yoshihiko, Tanaka"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-02-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "甲第298号_論文(田﨑園子).pdf", "filesize": [{"value": "880.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 880300.0, "url": {"label": "甲第298号_論文(田﨑園子)", "objectType": "fulltext", "url": "https://fdc.repo.nii.ac.jp/record/95/files/甲第298号_論文(田﨑園子).pdf"}, "version_id": "d9c5237b-5aa3-4925-8674-5a9d9634f2f1"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-02-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "甲第298号_論文内容の要旨(田﨑園子).pdf", "filesize": [{"value": "140.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 140400.0, "url": {"label": "甲第298号_論文内容の要旨(田﨑園子)", "url": "https://fdc.repo.nii.ac.jp/record/95/files/甲第298号_論文内容の要旨(田﨑園子).pdf"}, "version_id": "24d40adb-27c6-4729-93fa-9364b42d80f4"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-02-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "甲第298号_論文審査結果の要旨(田﨑園子).pdf", "filesize": [{"value": "231.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 231900.0, "url": {"label": "甲第298号_論文審査結果の要旨(田﨑園子)", "url": "https://fdc.repo.nii.ac.jp/record/95/files/甲第298号_論文審査結果の要旨(田﨑園子).pdf"}, "version_id": "fec87838-a8ac-4439-9aab-ee41708652b2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Candida albicans", "subitem_subject_language": "en"}, {"subitem_subject": "mycelial membranes", "subitem_subject_language": "en"}, {"subitem_subject": "Th17", "subitem_subject_language": "en"}, {"subitem_subject": "oral candidiasis", "subitem_subject_language": "en"}, {"subitem_subject": "adoptive transfer", "subitem_subject_language": "en"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis", "subitem_title_language": "en"}]}, "item_type_id": "10006", "owner": "15", "path": ["19"], "permalink_uri": "https://fdc.repo.nii.ac.jp/records/95", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-02-06"}, "publish_date": "2019-02-06", "publish_status": "0", "recid": "95", "relation": {}, "relation_version_is_last": true, "title": ["Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis"], "weko_shared_id": -1}