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  1. 学位論文
  2. 平成29(2017)年度
  3. 課程博士

Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis

https://fdc.repo.nii.ac.jp/records/95
https://fdc.repo.nii.ac.jp/records/95
3586a994-a3d2-4155-ab6d-1a42f5fb9969
名前 / ファイル ライセンス アクション
甲第298号_論文(田﨑園子).pdf 甲第298号_論文(田﨑園子) (880.3 kB)
甲第298号_論文内容の要旨(田﨑園子).pdf 甲第298号_論文内容の要旨(田﨑園子) (140.4 kB)
甲第298号_論文審査結果の要旨(田﨑園子).pdf 甲第298号_論文審査結果の要旨(田﨑園子) (231.9 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-02-06
タイトル
言語 en
タイトル Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis
言語
言語 eng
キーワード
言語 en
主題 Candida albicans
キーワード
言語 en
主題 mycelial membranes
キーワード
言語 en
主題 Th17
キーワード
言語 en
主題 oral candidiasis
キーワード
言語 en
主題 adoptive transfer
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Sonoko, Tasaki

× Sonoko, Tasaki

Sonoko, Tasaki

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Tamaki, Cho

× Tamaki, Cho

Tamaki, Cho

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Jun-ichi, Nagao

× Jun-ichi, Nagao

Jun-ichi, Nagao

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Shojiro, Ikezaki

× Shojiro, Ikezaki

Shojiro, Ikezaki

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Yuka, Narita

× Yuka, Narita

Yuka, Narita

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Ken-ichi, Arita-Morioka

× Ken-ichi, Arita-Morioka

Ken-ichi, Arita-Morioka

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Kanae, Yasumatsu

× Kanae, Yasumatsu

Kanae, Yasumatsu

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Keita, Toyoda

× Keita, Toyoda

Keita, Toyoda

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Hiroshi, Kojima

× Hiroshi, Kojima

Hiroshi, Kojima

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Yoshihiko, Tanaka

× Yoshihiko, Tanaka

Yoshihiko, Tanaka

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抄録
内容記述タイプ Abstract
内容記述 Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step.
学位名
学位名 博士(歯学)
学位授与大学
学位授与機関識別子 37114
学位授与機関名 福岡歯科大学
学位授与年度
内容記述 2017年度
学位授与年月日
学位授与年月日 2018-03-29
報告番号
学位授与番号 甲第298号
関連サイト
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/femsyr/foy018
関連名称 OXFORD
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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