| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2019-02-06 |
| タイトル |
|
|
タイトル |
Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
Candida albicans |
| キーワード |
|
|
言語 |
en |
|
主題 |
mycelial membranes |
| キーワード |
|
|
言語 |
en |
|
主題 |
Th17 |
| キーワード |
|
|
言語 |
en |
|
主題 |
oral candidiasis |
| キーワード |
|
|
言語 |
en |
|
主題 |
adoptive transfer |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Sonoko, Tasaki
Tamaki, Cho
Jun-ichi, Nagao
Shojiro, Ikezaki
Yuka, Narita
Ken-ichi, Arita-Morioka
Kanae, Yasumatsu
Keita, Toyoda
Hiroshi, Kojima
Yoshihiko, Tanaka
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2017年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2018-03-29 |
| 報告番号 |
|
|
学位授与番号 |
甲第298号 |
| 関連サイト |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1093/femsyr/foy018 |
|
|
関連名称 |
OXFORD |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第298号_論文(田﨑園子) (880.3 kB)
