{"created":"2023-05-15T09:58:10.425694+00:00","id":95,"links":{},"metadata":{"_buckets":{"deposit":"8d4272ba-af55-4694-9b30-a913fd407721"},"_deposit":{"created_by":15,"id":"95","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"95"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000095","sets":["1:17:19"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-29"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2017年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第298号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"OXFORD"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/femsyr/foy018","subitem_relation_type_select":"DOI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sonoko, Tasaki"}]},{"creatorNames":[{"creatorName":"Tamaki, Cho"}]},{"creatorNames":[{"creatorName":"Jun-ichi, Nagao"}]},{"creatorNames":[{"creatorName":"Shojiro, Ikezaki"}]},{"creatorNames":[{"creatorName":"Yuka, Narita"}]},{"creatorNames":[{"creatorName":"Ken-ichi, Arita-Morioka"}]},{"creatorNames":[{"creatorName":"Kanae, Yasumatsu"}]},{"creatorNames":[{"creatorName":"Keita, Toyoda"}]},{"creatorNames":[{"creatorName":"Hiroshi, Kojima"}]},{"creatorNames":[{"creatorName":"Yoshihiko, Tanaka"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-06"}],"displaytype":"detail","filename":"甲第298号_論文(田﨑園子).pdf","filesize":[{"value":"880.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第298号_論文(田﨑園子)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/95/files/甲第298号_論文(田﨑園子).pdf"},"version_id":"d9c5237b-5aa3-4925-8674-5a9d9634f2f1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-06"}],"displaytype":"detail","filename":"甲第298号_論文内容の要旨(田﨑園子).pdf","filesize":[{"value":"140.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第298号_論文内容の要旨(田﨑園子)","url":"https://fdc.repo.nii.ac.jp/record/95/files/甲第298号_論文内容の要旨(田﨑園子).pdf"},"version_id":"24d40adb-27c6-4729-93fa-9364b42d80f4"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-06"}],"displaytype":"detail","filename":"甲第298号_論文審査結果の要旨(田﨑園子).pdf","filesize":[{"value":"231.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第298号_論文審査結果の要旨(田﨑園子)","url":"https://fdc.repo.nii.ac.jp/record/95/files/甲第298号_論文審査結果の要旨(田﨑園子).pdf"},"version_id":"fec87838-a8ac-4439-9aab-ee41708652b2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Candida albicans","subitem_subject_language":"en"},{"subitem_subject":"mycelial membranes","subitem_subject_language":"en"},{"subitem_subject":"Th17","subitem_subject_language":"en"},{"subitem_subject":"oral candidiasis","subitem_subject_language":"en"},{"subitem_subject":"adoptive transfer","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["19"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-02-06"},"publish_date":"2019-02-06","publish_status":"0","recid":"95","relation_version_is_last":true,"title":["Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T02:14:09.218595+00:00"}