| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2017-11-16 |
| タイトル |
|
|
タイトル |
The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
toll-like recepter 2 |
| キーワード |
|
|
主題 |
Porphyromonas gingivalis |
| キーワード |
|
|
主題 |
LPS |
| キーワード |
|
|
主題 |
diabetic nephropathy |
| キーワード |
|
|
主題 |
eritoran |
| キーワード |
|
|
言語 |
en |
|
主題 |
toll-like recepter 2 |
| キーワード |
|
|
言語 |
en |
|
主題 |
Porphyromonas gingivalis |
| キーワード |
|
|
言語 |
en |
|
主題 |
LPS |
| キーワード |
|
|
言語 |
en |
|
主題 |
diabetic nephropathy |
| キーワード |
|
|
言語 |
en |
|
主題 |
eritoran |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Kajiwara, Koichiro
Takata, Shunsuke
To, Thao T
Takara, Kenyo
Hatakeyama, Yuji
Tamaoki, Sachio
Darveau, Richard Peters
Ishikawa, Hiroyuki
Sawa, Yoshihiko
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that periodontal pathogen Porphyromonas gingivalis LPS (Pg-LPS) administration lowered the survival rate of diabetic mice. The present study aims to examine the effect of TLR4 blocking on the suppression of Pg-LPS-induced diabetic nephropathy. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The survival rate and morphological/biochemical features for streptozotocin-induced diabetic mice with Pg-LPS and TLR4 blocker eritoran administration were investigated by reporter gene assay, urine and blood analysis, immunohistochemistry, and real time-PCR. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
All of the diabetic mice administered Pg-LPS were euthanized within the survival period of almost all of the diabetic mice. The blood urea nitrogen and creatinine, expression of TLR2 and TGF-b, and type 1 collagen accumulation, in the diabetic mice increased significantly with the Pg-LPS administration. In spite of the limited TLR4 activation with Pg-LPS, the TLR4 blocker eritoran decreased blood urea nitrogen and creatinine, and raised the survival rate of the Pg-LPS-administered diabetic mice slightly. The high expression levels of TLR2, TGF-b, and type 1 collagen in Pg-LPS-administered diabetic mice decreased with eritoran. Nuclear STAT3 which enhances TLR2 expression was detected in the TLR2-expressing glomeruli of diabetic mice. The TLR2 and STAT3 gene expression increased by the Pg-LPS administration but decreased with eritoran. These may suggest that Pg-LPS-induced diabetic nephropathy is mainly dependent on TLR2 signaling on glomerular endothelial cells, and that TLR4 blocker eritoran may play a role to slow the progress of diabetic nephropathy. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2017年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2017-10-31 |
| 報告番号 |
|
|
学位授与番号 |
甲第289号 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第289号_論文(梶原弘一郎) (3.1 MB)
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