{"created":"2023-05-15T09:58:09.886927+00:00","id":78,"links":{},"metadata":{"_buckets":{"deposit":"ea529e88-9c08-42e1-9c67-d5a4bad12587"},"_deposit":{"created_by":15,"id":"78","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"78"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000078","sets":["1:17:19"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-10-31"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2017年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that periodontal pathogen Porphyromonas gingivalis LPS (Pg-LPS) administration lowered the survival rate of diabetic mice. The present study aims to examine the effect of TLR4 blocking on the suppression of Pg-LPS-induced diabetic nephropathy.","subitem_description_type":"Abstract"},{"subitem_description":"The survival rate and morphological/biochemical features for streptozotocin-induced diabetic mice with Pg-LPS and TLR4 blocker eritoran administration were investigated by reporter gene assay, urine and blood analysis, immunohistochemistry, and real time-PCR.","subitem_description_type":"Abstract"},{"subitem_description":"All of the diabetic mice administered Pg-LPS were euthanized within the survival period of almost all of the diabetic mice. The blood urea nitrogen and creatinine, expression of TLR2 and TGF-b, and type 1 collagen accumulation, in the diabetic mice increased significantly with the Pg-LPS administration. In spite of the limited TLR4 activation with Pg-LPS, the TLR4 blocker eritoran decreased blood urea nitrogen and creatinine, and raised the survival rate of the Pg-LPS-administered diabetic mice slightly. The high expression levels of TLR2, TGF-b, and type 1 collagen in Pg-LPS-administered diabetic mice decreased with eritoran. Nuclear STAT3 which enhances TLR2 expression was detected in the TLR2-expressing glomeruli of diabetic mice. The TLR2 and STAT3 gene expression increased by the Pg-LPS administration but decreased with eritoran. These may suggest that Pg-LPS-induced diabetic nephropathy is mainly dependent on TLR2 signaling on glomerular endothelial cells, and that TLR4 blocker eritoran may play a role to slow the progress of diabetic nephropathy.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第289号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kajiwara, Koichiro"}]},{"creatorNames":[{"creatorName":"Takata, Shunsuke"}]},{"creatorNames":[{"creatorName":"To, Thao T"}]},{"creatorNames":[{"creatorName":"Takara, Kenyo"}]},{"creatorNames":[{"creatorName":"Hatakeyama, Yuji"}]},{"creatorNames":[{"creatorName":"Tamaoki, Sachio"}]},{"creatorNames":[{"creatorName":"Darveau, Richard Peters"}]},{"creatorNames":[{"creatorName":"Ishikawa, Hiroyuki"}]},{"creatorNames":[{"creatorName":"Sawa, Yoshihiko"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-16"}],"displaytype":"detail","filename":"甲第289号_論文(梶原弘一郎).pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第289号_論文(梶原弘一郎)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/78/files/甲第289号_論文(梶原弘一郎).pdf"},"version_id":"fe1002fb-3c67-4127-820d-a2e8dd57349c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-16"}],"displaytype":"detail","filename":"甲第289号_要旨(梶原弘一郎).pdf","filesize":[{"value":"127.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"要旨","url":"https://fdc.repo.nii.ac.jp/record/78/files/甲第289号_要旨(梶原弘一郎).pdf"},"version_id":"2542bab2-7ba7-4b8e-b06a-95461970ba57"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-16"}],"displaytype":"detail","filename":"甲第289号_論文審査結果の要旨(梶原弘一郎).pdf","filesize":[{"value":"177.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"審査結果の要旨","url":"https://fdc.repo.nii.ac.jp/record/78/files/甲第289号_論文審査結果の要旨(梶原弘一郎).pdf"},"version_id":"ecd1af75-028f-4c53-9718-9688d60c20d2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"toll-like recepter 2"},{"subitem_subject":"Porphyromonas gingivalis"},{"subitem_subject":"LPS"},{"subitem_subject":"diabetic nephropathy"},{"subitem_subject":"eritoran"},{"subitem_subject":"toll-like recepter 2","subitem_subject_language":"en"},{"subitem_subject":"Porphyromonas gingivalis","subitem_subject_language":"en"},{"subitem_subject":"LPS","subitem_subject_language":"en"},{"subitem_subject":"diabetic nephropathy","subitem_subject_language":"en"},{"subitem_subject":"eritoran","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["19"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-16"},"publish_date":"2017-11-16","publish_status":"0","recid":"78","relation_version_is_last":true,"title":["The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T02:13:45.214880+00:00"}