| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2017-03-29 |
| タイトル |
|
|
タイトル |
Intermittent administration of parathyroid hormone ameliorates periapical lesions in mice. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
リンフォトキシンアルファ |
| キーワード |
|
|
主題 |
好中球 |
| キーワード |
|
|
主題 |
副甲状腺ホルモン |
| キーワード |
|
|
主題 |
根尖性歯周炎 |
| キーワード |
|
|
言語 |
en |
|
主題 |
lymphotoxin alpha |
| キーワード |
|
|
言語 |
en |
|
主題 |
neutrophil infiltraion |
| キーワード |
|
|
言語 |
en |
|
主題 |
Animals |
| キーワード |
|
|
言語 |
en |
|
主題 |
Mice, Mutant Strains |
| キーワード |
|
|
言語 |
en |
|
主題 |
Neutrophil Infiltration |
| キーワード |
|
|
言語 |
en |
|
主題 |
Parathyroid Hormone |
| キーワード |
|
|
言語 |
en |
|
主題 |
Periapical Periodontitis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Otawa, Masato
Tanoue, Ryuichiro
Kido, Hirofumi
Sawa, Yoshihiko
Yamashita, Junro
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Intermittent administration of parathyroid hormone (PTH) promotes oral osseous wound healing and protects against ligature-induced alveolar bone loss. However, its therapeutic value on periapical periodontitis is unknown. The goal of this study was to determine the effect of intermittent PTH administration on the progression of periapical periodontitis. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Seven lymphotoxin alpha-deficient mice received pulp exposures of mandibular first and second molars. Exposed pulp in the right mandible was covered with plaque-contaminated fibrin, whereas exposed pulp in the left mandible was left open. After 4 weeks, the periapical tissues were examined to determine the effect of plaque-contaminated fibrin to induce periapical lesions. Fourteen mice received pulp exposure covered with plaque-contaminated fibrin. PTH (40 μg/kg/d) was administered intermittently to half of the mice for 3 weeks beginning 1 week after pulp exposure. The remaining half received saline injections as the vehicle control. At sacrifice, mandibles and tibiae were harvested and processed for histologic examination. Evaluation of neutrophils and blood vessels was performed after staining with immunofluorescence, and periradicular bone was histomorphometrically analyzed. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The exposed pulp covered with plaque-contaminated fibrin resulted in significantly larger periapical lesions compared with the control. Intermittent PTH administration reduced the size of periapical lesions significantly. Significantly less neutrophil infiltration around the root apex was found in PTH-treated animals compared with the control. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
PTH treatment suppressed periapical inflammation by reducing neutrophil infiltration and protected against tissue destruction by periapical periodontitis. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2016年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2017-03-11 |
| 報告番号 |
|
|
学位授与番号 |
甲第285号 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第285号_論文(大多和) (1.5 MB)
