{"created":"2023-05-15T09:58:09.718508+00:00","id":72,"links":{},"metadata":{"_buckets":{"deposit":"23040488-0745-4ed6-8748-37d68538705a"},"_deposit":{"created_by":15,"id":"72","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"72"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000072","sets":["1:14:15"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-11"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2016年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Intermittent administration of parathyroid hormone (PTH) promotes oral osseous wound healing and protects against ligature-induced alveolar bone loss. However, its therapeutic value on periapical periodontitis is unknown. The goal of this study was to determine the effect of intermittent PTH administration on the progression of periapical periodontitis.","subitem_description_type":"Abstract"},{"subitem_description":"Seven lymphotoxin alpha-deficient mice received pulp exposures of mandibular first and second molars. Exposed pulp in the right mandible was covered with plaque-contaminated fibrin, whereas exposed pulp in the left mandible was left open. After 4 weeks, the periapical tissues were examined to determine the effect of plaque-contaminated fibrin to induce periapical lesions. Fourteen mice received pulp exposure covered with plaque-contaminated fibrin. PTH (40 μg/kg/d) was administered intermittently to half of the mice for 3 weeks beginning 1 week after pulp exposure. The remaining half received saline injections as the vehicle control. At sacrifice, mandibles and tibiae were harvested and processed for histologic examination. Evaluation of neutrophils and blood vessels was performed after staining with immunofluorescence, and periradicular bone was histomorphometrically analyzed.","subitem_description_type":"Abstract"},{"subitem_description":"The exposed pulp covered with plaque-contaminated fibrin resulted in significantly larger periapical lesions compared with the control. Intermittent PTH administration reduced the size of periapical lesions significantly. Significantly less neutrophil infiltration around the root apex was found in PTH-treated animals compared with the control.","subitem_description_type":"Abstract"},{"subitem_description":"PTH treatment suppressed periapical inflammation by reducing neutrophil infiltration and protected against tissue destruction by periapical periodontitis.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第285号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Otawa, Masato"}]},{"creatorNames":[{"creatorName":"Tanoue, Ryuichiro"}]},{"creatorNames":[{"creatorName":"Kido, Hirofumi"}]},{"creatorNames":[{"creatorName":"Sawa, Yoshihiko"}]},{"creatorNames":[{"creatorName":"Yamashita, Junro"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-29"}],"displaytype":"detail","filename":"甲第285号_論文(大多和).pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"甲第285号_論文(大多和).pdf","mimetype":"application/pdf","url":{"label":"甲第285号_論文(大多和)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/72/files/甲第285号_論文(大多和).pdf"},"version_id":"1dd6246f-0e8a-4feb-bf0f-a42720ec6d75"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-29"}],"displaytype":"detail","filename":"甲第285号_論文内容の要旨(大多和).pdf","filesize":[{"value":"174.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://fdc.repo.nii.ac.jp/record/72/files/甲第285号_論文内容の要旨(大多和).pdf"},"version_id":"a256613b-7ff5-4223-9432-86ddfac154d2"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-29"}],"displaytype":"detail","filename":"甲第285号_論文審査結果の要旨(大多和).pdf","filesize":[{"value":"176.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果の要旨","url":"https://fdc.repo.nii.ac.jp/record/72/files/甲第285号_論文審査結果の要旨(大多和).pdf"},"version_id":"31822df4-a1da-4688-947f-6069a55d69dd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"リンフォトキシンアルファ"},{"subitem_subject":"好中球"},{"subitem_subject":"副甲状腺ホルモン"},{"subitem_subject":"根尖性歯周炎"},{"subitem_subject":"lymphotoxin alpha","subitem_subject_language":"en"},{"subitem_subject":"neutrophil infiltraion","subitem_subject_language":"en"},{"subitem_subject":"Animals","subitem_subject_language":"en"},{"subitem_subject":"Mice, Mutant Strains","subitem_subject_language":"en"},{"subitem_subject":"Neutrophil Infiltration","subitem_subject_language":"en"},{"subitem_subject":"Parathyroid Hormone","subitem_subject_language":"en"},{"subitem_subject":"Periapical Periodontitis","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Intermittent administration of parathyroid hormone ameliorates periapical lesions in mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intermittent administration of parathyroid hormone ameliorates periapical lesions in mice.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["15"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-03-29"},"publish_date":"2017-03-29","publish_status":"0","recid":"72","relation_version_is_last":true,"title":["Intermittent administration of parathyroid hormone ameliorates periapical lesions in mice."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-16T00:39:53.541191+00:00"}