| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2014-06-16 |
| タイトル |
|
|
タイトル |
Dynamic changes in cell-surface expression of mannose in the oral epithelium during the development of graft-versus-host disease of the oral mucosa in rats. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Graft versus host disease |
| キーワード |
|
|
主題 |
CD8⁺lymphocytes |
| キーワード |
|
|
主題 |
Lens culinaris lectin |
| キーワード |
|
|
主題 |
Mannose-binding protein |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Hanada, Hironori
Ohno, Jun
Seno, Kei
Ota, Nobutaka
Taniguchi, Kunihisa
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The role of cell-surface glycoconjugates in oral mucosal graft-versus-host disease (GVHD) is still unclear, even though molecular changes in the oral epithelium are essential for the pathogenesis of these lesions. In this study, we investigated changes in the binding of mannose (Man)-specific Lens culinaris lectin (LCA) in the oral mucosa of rats with GVHD. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Lewis rat spleen cells were injected into (Lewis x Brown Norway) F1 rats to induce systemic GVHD, including oral mucosal lesions. Tongue and spleen samples were evaluated using lectin histochemistry, immunohistochemistry, Western blotting, transwell migration assays and Stamper-Woodruff binding assays. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Binding of Man-specific LCA expanded to the epithelial layers of the tongue in GVHD-rats. An expansion of LCA binding was related to the increased expression of mannosyltransferase in the oral mucosa. CD8+ cells, effector cells of oral mucosal GVHD, expressed mannose-binding protein (MBP) and migrated to the medium containing Man in the transwell migration assay. Adherence of CD8+ cells to the oral epithelium could be inhibited by pretreating CD8+ cells with MBP antibody and/or by pretreating sections with Man-specific LCA. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Increased expression of Man on keratinocytes leads to the migration and/or adhesion of CD8+ cells in the surface epithelium, which is mediated in part by the MBP/Man-binding pathway during the development of oral mucosal GVHD. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2013年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2014-03-31 |
| 報告番号 |
|
|
学位授与番号 |
乙第92号 |
| 情報源 |
|
|
|
関連名称 |
BMC Oral Health. 2014 Jan 16;14:5. doi: 10.1186/1472-6831-14-5. |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.biomedcentral.com/1472-6831/14/5 |
|
|
関連名称 |
BioMed Central |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
乙第92号_論文(花田) (3.2 MB)
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