{"created":"2023-05-15T09:58:07.813776+00:00","id":24,"links":{},"metadata":{"_buckets":{"deposit":"9b177257-9097-4bb7-9bed-6ea0eae4f468"},"_deposit":{"created_by":15,"id":"24","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"24"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000024","sets":["1:3:5"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-31"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The role of cell-surface glycoconjugates in oral mucosal graft-versus-host disease (GVHD) is still unclear, even though molecular changes in the oral epithelium are essential for the pathogenesis of these lesions. In this study, we investigated changes in the binding of mannose (Man)-specific Lens culinaris lectin (LCA) in the oral mucosa of rats with GVHD.","subitem_description_type":"Abstract"},{"subitem_description":"Lewis rat spleen cells were injected into (Lewis x Brown Norway) F1 rats to induce systemic GVHD, including oral mucosal lesions. Tongue and spleen samples were evaluated using lectin histochemistry, immunohistochemistry, Western blotting, transwell migration assays and Stamper-Woodruff binding assays.","subitem_description_type":"Abstract"},{"subitem_description":"Binding of Man-specific LCA expanded to the epithelial layers of the tongue in GVHD-rats. An expansion of LCA binding was related to the increased expression of mannosyltransferase in the oral mucosa. CD8+ cells, effector cells of oral mucosal GVHD, expressed mannose-binding protein (MBP) and migrated to the medium containing Man in the transwell migration assay. Adherence of CD8+ cells to the oral epithelium could be inhibited by pretreating CD8+ cells with MBP antibody and/or by pretreating sections with Man-specific LCA.","subitem_description_type":"Abstract"},{"subitem_description":"Increased expression of Man on keratinocytes leads to the migration and/or adhesion of CD8+ cells in the surface epithelium, which is mediated in part by the MBP/Man-binding pathway during the development of oral mucosal GVHD.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第92号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"BMC Oral Health. 2014 Jan 16;14:5. doi: 10.1186/1472-6831-14-5."}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"BioMed Central"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.biomedcentral.com/1472-6831/14/5","subitem_relation_type_select":"URI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hanada, Hironori"}]},{"creatorNames":[{"creatorName":"Ohno, Jun"}]},{"creatorNames":[{"creatorName":"Seno, Kei"}]},{"creatorNames":[{"creatorName":"Ota, Nobutaka"}]},{"creatorNames":[{"creatorName":"Taniguchi, Kunihisa"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-06-16"}],"displaytype":"detail","filename":"乙第92号_論文(花田).pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"乙第92号_論文(花田)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/24/files/乙第92号_論文(花田).pdf"},"version_id":"e5dcef43-77ab-4506-a5aa-de7cdddaaf82"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-06-16"}],"displaytype":"detail","filename":"乙第92号_論文の要旨(花田).pdf","filesize":[{"value":"81.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://fdc.repo.nii.ac.jp/record/24/files/乙第92号_論文の要旨(花田).pdf"},"version_id":"be52324e-6269-4ffa-8d7c-47de2559d52f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-06-16"}],"displaytype":"detail","filename":"乙第92号_論文審査結果の要旨(花田).pdf","filesize":[{"value":"249.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果の要旨","url":"https://fdc.repo.nii.ac.jp/record/24/files/乙第92号_論文審査結果の要旨(花田).pdf"},"version_id":"785e33a4-6a3f-4b36-b089-2a4e808310e6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Graft versus host disease"},{"subitem_subject":"CD8⁺lymphocytes"},{"subitem_subject":"Lens culinaris lectin"},{"subitem_subject":"Mannose-binding protein"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Dynamic changes in cell-surface expression of mannose in the oral epithelium during the development of graft-versus-host disease of the oral mucosa in rats.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dynamic changes in cell-surface expression of mannose in the oral epithelium during the development of graft-versus-host disease of the oral mucosa in rats.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-06-16"},"publish_date":"2014-06-16","publish_status":"0","recid":"24","relation_version_is_last":true,"title":["Dynamic changes in cell-surface expression of mannose in the oral epithelium during the development of graft-versus-host disease of the oral mucosa in rats."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T01:56:43.369460+00:00"}