| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2021-05-24 |
| タイトル |
|
|
タイトル |
Enhancement of jaw bone regeneration via ERK1/2 activation using dedifferentiated fat cells. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
骨再生 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
DFAT |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
脂肪組織由来間葉系幹/間質細胞 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
細胞移植 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
下顎骨欠損 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bone regeneration |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dedifferentiated fat cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Adipose tissue-derived mesenchymal stem/stromal cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cell transplantation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Mandibular defect |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Fujisaki, Seiichi
Kajiya, Hiroshi
Yanagi, Tsukasa
Maeshiba, Munehisa
Kakura, Kae
Kido, Hirofumi
Ohno, Jun
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Mesenchymal stem/stromal cells (MSCs) are multipotent and self-renewing cells that are extensively used in tissue engineering. Adipose tissues are known to be the source of two types of MSCs; namely, adipose tissue-derived MSCs (ASCs) and dedifferentiated fat (DFAT) cells. Although ASCs are sometimes transplanted for clinical cytotherapy, the effects of DFAT cell transplantation on mandibular bone healing remain unclear. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The authors assessed whether DFAT cells have osteogenerative potential compared with ASCs in rats in vitro. In addition, to elucidate the ability of DFAT cells to regenerate the jaw bone, the authors examined the effects of DFAT cells on new bone formation in a mandibular defect model in (i) 30-week-old rats and (ii) ovariectomy-induced osteoporotic rats in vivo. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Osteoblast differentiation with bone morphogenetic protein 2 (BMP-2) or osteogenesis-induced medium upregulated the osteogenesis-related molecules in DFAT cells compared with those in ASCs. BMP-2 activated the phosphorylation signaling pathways of ERK1/2 and Smad2 in DFAT cells, but minor Smad1/5/9 activation was noted in ASCs. The transplantation of DFAT cells into normal or ovariectomy-induced osteoporotic rats with mandibular defects promoted new bone formation compared with that seen with ASCs. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
DFAT cells promoted osteoblast differentiation and new bone formation through ERK1/2 and Smad2 signaling pathways in vitro. The transplantation of DFAT cells promoted new mandibular bone formation in vivo compared with that seen with ASCs. These results suggest that transplantation of ERK1/2-activated DFAT cells shorten the mandibular bone healing process in cytotherapy. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
2020年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2021-03-31 |
| 報告番号 |
|
|
学位授与番号 |
甲第332号 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第332号_論文(藤﨑誠一) (949.5 kB)
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