{"created":"2023-05-15T09:58:11.988457+00:00","id":132,"links":{},"metadata":{"_buckets":{"deposit":"c0213b5a-723f-4540-bfc7-8c2bf1b58b1d"},"_deposit":{"created_by":15,"id":"132","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"132"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000132","sets":["1:26:27"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-03-31"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学 "}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2020年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mesenchymal stem/stromal cells (MSCs) are multipotent and self-renewing cells that are extensively used in tissue engineering. Adipose tissues are known to be the source of two types of MSCs; namely, adipose tissue-derived MSCs (ASCs) and dedifferentiated fat (DFAT) cells. Although ASCs are sometimes transplanted for clinical cytotherapy, the effects of DFAT cell transplantation on mandibular bone healing remain unclear.","subitem_description_type":"Abstract"},{"subitem_description":"The authors assessed whether DFAT cells have osteogenerative potential compared with ASCs in rats in vitro. In addition, to elucidate the ability of DFAT cells to regenerate the jaw bone, the authors examined the effects of DFAT cells on new bone formation in a mandibular defect model in (i) 30-week-old rats and (ii) ovariectomy-induced osteoporotic rats in vivo.","subitem_description_type":"Abstract"},{"subitem_description":"Osteoblast differentiation with bone morphogenetic protein 2 (BMP-2) or osteogenesis-induced medium upregulated the osteogenesis-related molecules in DFAT cells compared with those in ASCs. BMP-2 activated the phosphorylation signaling pathways of ERK1/2 and Smad2 in DFAT cells, but minor Smad1/5/9 activation was noted in ASCs. The transplantation of DFAT cells into normal or ovariectomy-induced osteoporotic rats with mandibular defects promoted new bone formation compared with that seen with ASCs.","subitem_description_type":"Abstract"},{"subitem_description":"DFAT cells promoted osteoblast differentiation and new bone formation through ERK1/2 and Smad2 signaling pathways in vitro. The transplantation of DFAT cells promoted new mandibular bone formation in vivo compared with that seen with ASCs. These results suggest that transplantation of ERK1/2-activated DFAT cells shorten the mandibular bone healing process in cytotherapy.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第332号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujisaki, Seiichi"}]},{"creatorNames":[{"creatorName":"Kajiya, Hiroshi"}]},{"creatorNames":[{"creatorName":"Yanagi, Tsukasa"}]},{"creatorNames":[{"creatorName":"Maeshiba, Munehisa"}]},{"creatorNames":[{"creatorName":"Kakura, Kae"}]},{"creatorNames":[{"creatorName":"Kido, Hirofumi"}]},{"creatorNames":[{"creatorName":"Ohno, Jun"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-17"}],"displaytype":"detail","filename":"甲第332号_論文(藤﨑誠一).pdf","filesize":[{"value":"949.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第332号_論文(藤﨑誠一)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/132/files/甲第332号_論文(藤﨑誠一).pdf"},"version_id":"22bb277e-2a12-4328-be17-d6e6a2926c63"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-24"}],"displaytype":"detail","filename":"甲第332号_論文内容の要旨(藤﨑誠一).pdf","filesize":[{"value":"242.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第332号_論文内容の要旨(藤﨑誠一)","url":"https://fdc.repo.nii.ac.jp/record/132/files/甲第332号_論文内容の要旨(藤﨑誠一).pdf"},"version_id":"e877fab4-0d53-4bd0-9f24-641ca0de3f34"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-24"}],"displaytype":"detail","filename":"甲第332号_論文審査結果の要旨(藤﨑誠一).pdf","filesize":[{"value":"81.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第332号_論文審査結果の要旨(藤﨑誠一)","url":"https://fdc.repo.nii.ac.jp/record/132/files/甲第332号_論文審査結果の要旨(藤﨑誠一).pdf"},"version_id":"942992c0-a1ca-47b1-8be3-bb4483e1c292"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨再生","subitem_subject_scheme":"Other"},{"subitem_subject":"DFAT","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪組織由来間葉系幹/間質細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞移植","subitem_subject_scheme":"Other"},{"subitem_subject":"下顎骨欠損","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone regeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dedifferentiated fat cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Adipose tissue-derived mesenchymal stem/stromal cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell transplantation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mandibular defect","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Enhancement of jaw bone regeneration via ERK1/2 activation using dedifferentiated fat cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enhancement of jaw bone regeneration via ERK1/2 activation using dedifferentiated fat cells.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["27"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-05-24"},"publish_date":"2021-05-24","publish_status":"0","recid":"132","relation_version_is_last":true,"title":["Enhancement of jaw bone regeneration via ERK1/2 activation using dedifferentiated fat cells."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-11T01:10:33.363398+00:00"}