| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-06-17 |
| タイトル |
|
|
タイトル |
Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Tooth root |
| キーワード |
|
|
主題 |
Cyclophosphamide |
| キーワード |
|
|
主題 |
Hertwig’s epithelial root sheath |
| キーワード |
|
|
主題 |
Epithelial-to-mesenchymal transition |
| キーワード |
|
|
言語 |
en |
|
主題 |
Tooth root |
| キーワード |
|
|
言語 |
en |
|
主題 |
Cyclophosphamide |
| キーワード |
|
|
言語 |
en |
|
主題 |
Hertwig’s epithelial root sheath |
| キーワード |
|
|
言語 |
en |
|
主題 |
Epithelial-to-mesenchymal transition |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Matsuo, Satoru
Toda-Nakamura, Masako
Oka, Kyoko
Kajiya, Hiroshi
Ogata, Kayoko
Ishii, Hanako
Ozaki, Masao
Ohno, Jun
|
| 公開者 |
|
|
出版者 |
硬組織再生生物学会 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
<p>Cyclophosphamide (CPA) is a commonly used chemotherapeutic agent to treat cancer. Among its many side effects is the well-known consequence on tooth development when administered at early ages. This study elucidated the effects of CPA on development of the mandibular molar in mice. Mice received a single intraperitoneal injection of CPA at different doses and development times. CPA treatment led to weight loss and alopecia but had no effect on disturbances in tooth eruption or crown shape. However, at higher doses, there was arrested root development and early apical foramen closure histologically related to the formation of the cervical loop structure in the apical portion of the root. In cell culture experiments, the Hertwig's epithelial root sheath cell line (HERS01a) was cultured with or without CPA. At high doses of CPA, HERS01a cells showed decreases in E-cadherin expression, while N-cadherin expression was upregulated, indicating that this cadherin switch may promote an epithelial-to-mesenchymal transition (EMT)-like phenomenon. These findings suggest that administration of high doses of CPA can lead to arrested root development of the molars and an EMT-like phenomenon.</p> |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2019年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2020-03-14 |
| 報告番号 |
|
|
学位授与番号 |
甲第314号 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第314号_論文(松尾聡) (5.2 MB)
