{"created":"2023-05-15T09:58:11.462404+00:00","id":121,"links":{},"metadata":{"_buckets":{"deposit":"a37edfdf-0d74-41cd-ac9f-6cb637369cd9"},"_deposit":{"created_by":15,"id":"121","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"121"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000121","sets":["1:23:25"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-14"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2019年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"<p>Cyclophosphamide (CPA) is a commonly used chemotherapeutic agent to treat cancer. Among its many side effects is the well-known consequence on tooth development when administered at early ages. This study elucidated the effects of CPA on development of the mandibular molar in mice. Mice received a single intraperitoneal injection of CPA at different doses and development times. CPA treatment led to weight loss and alopecia but had no effect on disturbances in tooth eruption or crown shape. However, at higher doses, there was arrested root development and early apical foramen closure histologically related to the formation of the cervical loop structure in the apical portion of the root. In cell culture experiments, the Hertwig's epithelial root sheath cell line (HERS01a) was cultured with or without CPA. At high doses of CPA, HERS01a cells showed decreases in E-cadherin expression, while N-cadherin expression was upregulated, indicating that this cadherin switch may promote an epithelial-to-mesenchymal transition (EMT)-like phenomenon. These findings suggest that administration of high doses of CPA can lead to arrested root development of the molars and an EMT-like phenomenon.</p>","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第314号"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"硬組織再生生物学会"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuo, Satoru"}]},{"creatorNames":[{"creatorName":"Toda-Nakamura, Masako"}]},{"creatorNames":[{"creatorName":"Oka, Kyoko"}]},{"creatorNames":[{"creatorName":"Kajiya, Hiroshi"}]},{"creatorNames":[{"creatorName":"Ogata, Kayoko"}]},{"creatorNames":[{"creatorName":"Ishii, Hanako"}]},{"creatorNames":[{"creatorName":"Ozaki, Masao"}]},{"creatorNames":[{"creatorName":"Ohno, Jun"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-17"}],"displaytype":"detail","filename":"甲第314号_論文(松尾聡).pdf","filesize":[{"value":"5.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第314号_論文(松尾聡)","url":"https://fdc.repo.nii.ac.jp/record/121/files/甲第314号_論文(松尾聡).pdf"},"version_id":"d96fd2c3-d127-4918-b688-3a7c01f94280"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-17"}],"displaytype":"detail","filename":"甲第314号_論文内容の要旨(松尾聡).pdf","filesize":[{"value":"143.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第314号_論文内容の要旨(松尾聡)","url":"https://fdc.repo.nii.ac.jp/record/121/files/甲第314号_論文内容の要旨(松尾聡).pdf"},"version_id":"c809588d-31be-443e-9815-51937a03bdae"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-17"}],"displaytype":"detail","filename":"甲第314号_論文審査結果の要旨(松尾聡).pdf","filesize":[{"value":"185.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第314号_論文審査結果の要旨(松尾聡)","url":"https://fdc.repo.nii.ac.jp/record/121/files/甲第314号_論文審査結果の要旨(松尾聡).pdf"},"version_id":"3c3d68e7-511d-414d-acbe-f3f0cbf965ba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tooth root"},{"subitem_subject":"Cyclophosphamide"},{"subitem_subject":"Hertwig’s epithelial root sheath"},{"subitem_subject":"Epithelial-to-mesenchymal transition"},{"subitem_subject":"Tooth root","subitem_subject_language":"en"},{"subitem_subject":"Cyclophosphamide","subitem_subject_language":"en"},{"subitem_subject":"Hertwig’s epithelial root sheath","subitem_subject_language":"en"},{"subitem_subject":"Epithelial-to-mesenchymal transition","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["25"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-17"},"publish_date":"2020-06-17","publish_status":"0","recid":"121","relation_version_is_last":true,"title":["Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T02:16:48.116626+00:00"}