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Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma.
https://fdc.repo.nii.ac.jp/records/113
https://fdc.repo.nii.ac.jp/records/113e186cc71-4b5e-4151-8774-a2da219a1caa
| 名前 / ファイル | ライセンス | アクション |
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甲第318号_論文(首藤俊一) (1.2 MB)
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甲第318号_論文内容の要旨(首藤俊一) (146.7 kB)
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甲第318号_論文審査結果の要旨(首藤俊一) (226.1 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||||||||||||||
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| 公開日 | 2020-03-25 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma. | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | cisplatin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | metastasis | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | oral squamous cell carcinoma | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | programmed cell death ligand 2 | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | signal transducers and activator of transcription 1/3 | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | cisplatin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | metastasis | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | oral squamous cell carcinoma | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | programmed cell death ligand 2 | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題 | signal transducers and activator of transcription 1/3 | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||||||||||||||
| 資源タイプ | doctoral thesis | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||
| 著者 |
Sudo, Shunichi
× Sudo, Shunichi
× Kajiya, Hiroshi
× Okano, Shinji
× Sasaki, Mina
× Katsumata, Yuri
× Ohno, Jun
× Ikebe, Tetsuro
× Hiraki, Akimitsu
× Okabe, Koji
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| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Programmed cell death ligands (PD-Ls) are expressed in tumor cells where they bind to programmed cell death-1, an immunocyte co-receptor, resulting in tumor cell evasion from the immune system. Chemotherapeutic drugs have been recently reported to induce the expression of PD-L, such as PD-L1, in some cancer cells. However, little is known regarding PD-L2 expression and its role in oral squamous cell carcinoma (OSCC). In this study, we examined the effect of cisplatin on the expression and regulation of PD-L2 in OSCC cell lines and analyzed malignant behavior in PD-L2-expressing cells using colony, transwell and transformation assays. In addition, we examined PD-L2 expression in the tumor tissues of OSCC patients using cytology and tissue microarray methods. In OSCC cell lines, cisplatin treatment upregulated PD-L2 expression, along with that of the drug efflux transporter ABCG2, via signal transducers and activator of transcription (STAT) 1/3 activation. Moreover, PD-L2-positive or PD-L2-overexpressing cells demonstrated upregulation in both invasion and transformation ability but not in proliferation compared with PD-L2-negative or PD-L2-silencing cells. PD-L2 expression was also observed in OSCC cells of cytology samples and tissue from OSCC patients. The intensity of PD-L2 expression was correlated with more malignant morphological features in the histological appearance and an invasive pattern. Our findings indicate that cisplatin-upregulated PD-L2 expression in OSCC via STAT1/3 activation and the expression of PD-L2 are likely to be associated with malignancy in OSCC. The PD-L2 expression in cisplatin-resistant OSCC cells may be a critical factor in prognosis of advanced OSCC patients. | |||||||||||||||||||||||
| 学位名 | ||||||||||||||||||||||||
| 学位名 | 博士（歯学） | |||||||||||||||||||||||
| 学位授与大学 | ||||||||||||||||||||||||
| 学位授与機関識別子 | 37114 | |||||||||||||||||||||||
| 学位授与機関名 | 福岡歯科大学 | |||||||||||||||||||||||
| 学位授与年度 | ||||||||||||||||||||||||
| 内容記述 | 2019年度 | |||||||||||||||||||||||
| 学位授与年月日 | ||||||||||||||||||||||||
| 学位授与年月日 | 2020-03-14 | |||||||||||||||||||||||
| 報告番号 | ||||||||||||||||||||||||
| 学位授与番号 | 甲第318号 | |||||||||||||||||||||||
| 関連サイト | ||||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1111/cas.14336 | |||||||||||||||||||||||
| 関連名称 | Wiley | |||||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
