| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2020-03-25 |
| タイトル |
|
|
タイトル |
Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
cisplatin |
| キーワード |
|
|
主題 |
metastasis |
| キーワード |
|
|
主題 |
oral squamous cell carcinoma |
| キーワード |
|
|
主題 |
programmed cell death ligand 2 |
| キーワード |
|
|
主題 |
signal transducers and activator of transcription 1/3 |
| キーワード |
|
|
言語 |
en |
|
主題 |
cisplatin |
| キーワード |
|
|
言語 |
en |
|
主題 |
metastasis |
| キーワード |
|
|
言語 |
en |
|
主題 |
oral squamous cell carcinoma |
| キーワード |
|
|
言語 |
en |
|
主題 |
programmed cell death ligand 2 |
| キーワード |
|
|
言語 |
en |
|
主題 |
signal transducers and activator of transcription 1/3 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Sudo, Shunichi
Kajiya, Hiroshi
Okano, Shinji
Sasaki, Mina
Katsumata, Yuri
Ohno, Jun
Ikebe, Tetsuro
Hiraki, Akimitsu
Okabe, Koji
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Programmed cell death ligands (PD-Ls) are expressed in tumor cells where they bind to programmed cell death-1, an immunocyte co-receptor, resulting in tumor cell evasion from the immune system. Chemotherapeutic drugs have been recently reported to induce the expression of PD-L, such as PD-L1, in some cancer cells. However, little is known regarding PD-L2 expression and its role in oral squamous cell carcinoma (OSCC). In this study, we examined the effect of cisplatin on the expression and regulation of PD-L2 in OSCC cell lines and analyzed malignant behavior in PD-L2-expressing cells using colony, transwell and transformation assays. In addition, we examined PD-L2 expression in the tumor tissues of OSCC patients using cytology and tissue microarray methods. In OSCC cell lines, cisplatin treatment upregulated PD-L2 expression, along with that of the drug efflux transporter ABCG2, via signal transducers and activator of transcription (STAT) 1/3 activation. Moreover, PD-L2-positive or PD-L2-overexpressing cells demonstrated upregulation in both invasion and transformation ability but not in proliferation compared with PD-L2-negative or PD-L2-silencing cells. PD-L2 expression was also observed in OSCC cells of cytology samples and tissue from OSCC patients. The intensity of PD-L2 expression was correlated with more malignant morphological features in the histological appearance and an invasive pattern. Our findings indicate that cisplatin-upregulated PD-L2 expression in OSCC via STAT1/3 activation and the expression of PD-L2 are likely to be associated with malignancy in OSCC. The PD-L2 expression in cisplatin-resistant OSCC cells may be a critical factor in prognosis of advanced OSCC patients. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2019年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2020-03-14 |
| 報告番号 |
|
|
学位授与番号 |
甲第318号 |
| 関連サイト |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/cas.14336 |
|
|
関連名称 |
Wiley |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第318号_論文(首藤俊一) (1.2 MB)
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