{"created":"2023-05-15T09:58:11.161544+00:00","id":113,"links":{},"metadata":{"_buckets":{"deposit":"1feeba93-0f5c-496e-b740-4483a3c7931e"},"_deposit":{"created_by":15,"id":"113","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"113"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000113","sets":["1:23:25"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-14"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2019年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Programmed cell death ligands (PD-Ls) are expressed in tumor cells where they bind to programmed cell death-1, an immunocyte co-receptor, resulting in tumor cell evasion from the immune system. Chemotherapeutic drugs have been recently reported to induce the expression of PD-L, such as PD-L1, in some cancer cells. However, little is known regarding PD-L2 expression and its role in oral squamous cell carcinoma (OSCC). In this study, we examined the effect of cisplatin on the expression and regulation of PD-L2 in OSCC cell lines and analyzed malignant behavior in PD-L2-expressing cells using colony, transwell and transformation assays. In addition, we examined PD-L2 expression in the tumor tissues of OSCC patients using cytology and tissue microarray methods. In OSCC cell lines, cisplatin treatment upregulated PD-L2 expression, along with that of the drug efflux transporter ABCG2, via signal transducers and activator of transcription (STAT) 1/3 activation. Moreover, PD-L2-positive or PD-L2-overexpressing cells demonstrated upregulation in both invasion and transformation ability but not in proliferation compared with PD-L2-negative or PD-L2-silencing cells. PD-L2 expression was also observed in OSCC cells of cytology samples and tissue from OSCC patients. The intensity of PD-L2 expression was correlated with more malignant morphological features in the histological appearance and an invasive pattern. Our findings indicate that cisplatin-upregulated PD-L2 expression in OSCC via STAT1/3 activation and the expression of PD-L2 are likely to be associated with malignancy in OSCC. The PD-L2 expression in cisplatin-resistant OSCC cells may be a critical factor in prognosis of advanced OSCC patients.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第318号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Wiley"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/cas.14336","subitem_relation_type_select":"DOI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sudo, Shunichi"}]},{"creatorNames":[{"creatorName":"Kajiya, Hiroshi"}]},{"creatorNames":[{"creatorName":"Okano, Shinji"}]},{"creatorNames":[{"creatorName":"Sasaki, Mina"}]},{"creatorNames":[{"creatorName":"Katsumata, Yuri"}]},{"creatorNames":[{"creatorName":"Ohno, Jun"}]},{"creatorNames":[{"creatorName":"Ikebe, Tetsuro"}]},{"creatorNames":[{"creatorName":"Hiraki, Akimitsu"}]},{"creatorNames":[{"creatorName":"Okabe, Koji"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-25"}],"displaytype":"detail","filename":"甲第318号_論文(首藤俊一).pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第318号_論文(首藤俊一)","url":"https://fdc.repo.nii.ac.jp/record/113/files/甲第318号_論文(首藤俊一).pdf"},"version_id":"f2f8430a-d680-4e36-8e41-529d43ec0b2f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-25"}],"displaytype":"detail","filename":"甲第318号_論文内容の要旨(首藤俊一).pdf","filesize":[{"value":"146.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第318号_論文内容の要旨(首藤俊一)","url":"https://fdc.repo.nii.ac.jp/record/113/files/甲第318号_論文内容の要旨(首藤俊一).pdf"},"version_id":"63ae6bed-2f56-45a9-b161-5054b85afa19"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-25"}],"displaytype":"detail","filename":"甲第318号_論文審査結果の要旨(首藤俊一).pdf","filesize":[{"value":"226.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲第318号_論文審査結果の要旨(首藤俊一)","url":"https://fdc.repo.nii.ac.jp/record/113/files/甲第318号_論文審査結果の要旨(首藤俊一).pdf"},"version_id":"bb2a1259-f737-4f6e-8341-cd3b466b96f1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cisplatin"},{"subitem_subject":"metastasis"},{"subitem_subject":"oral squamous cell carcinoma"},{"subitem_subject":"programmed cell death ligand 2"},{"subitem_subject":"signal transducers and activator of transcription 1/3"},{"subitem_subject":"cisplatin","subitem_subject_language":"en"},{"subitem_subject":"metastasis","subitem_subject_language":"en"},{"subitem_subject":"oral squamous cell carcinoma","subitem_subject_language":"en"},{"subitem_subject":"programmed cell death ligand 2","subitem_subject_language":"en"},{"subitem_subject":"signal transducers and activator of transcription 1/3","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["25"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-25"},"publish_date":"2020-03-25","publish_status":"0","recid":"113","relation_version_is_last":true,"title":["Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T02:16:35.598858+00:00"}