| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2018-05-24 |
| タイトル |
|
|
タイトル |
Degradation rate of DNA scaffolds and bone regeneration. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
biodegradation |
| キーワード |
|
|
言語 |
en |
|
主題 |
bone regeneration |
| キーワード |
|
|
言語 |
en |
|
主題 |
calvarial defect |
| キーワード |
|
|
言語 |
en |
|
主題 |
phosphate |
| キーワード |
|
|
言語 |
en |
|
主題 |
scaffold |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Matsumoto, Ayako
Kajiya, Hiroshi
Yamamoto-M, Nana
Yanagi, Tsukasa
Imamura, Ayaka
Okabe, Koji
Fukushima, Tadao
Kido, Hirofumi
Ohno, Jun
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Scaffolds implanted into bone defect sites must achieve optimal biodegradation rates while appropriately filling the void as new bone formation progresses. We recently developed a unique biomaterial consisting of salmon deoxyribose nucleic acid (DNA) and protamine, which can be used as an osteoconductive scaffold for tissue engineering. The aim of the present study was to elucidate how the degradation rate of the scaffold affects bone regeneration. We examined the relationships between the degradation rate of salmon DNA scaffolds and new bone formation using a rat skin flank subcutaneous model and rat calvarial defect model. The degradation rates of the scaffolds were proportional to the durations of pretreatment with ultraviolet (UV) light irradiation. The biodegradation rates of the scaffolds were also dependent on the duration of UV irradiation, as tested a subcutaneous tissue implantation. Scaffolds irradiated with UV light for 0.5 h maintained gradual biodegradation of phosphate compared with scaffolds irradiated for 0 or 3 h. In the calvarial defect model, we found that new bone formation was higher in rats treated with scaffolds irradiated with UV light for 0.5 h compared with those irradiated with UV light for 0 or 3.0 h. The present results suggest that bioengineering of scaffolds for biodegradation is important to regenerate bone. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2017年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2018-03-29 |
| 報告番号 |
|
|
学位授与番号 |
甲第296号 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第296号_論文(松本彩子) (1.7 MB)
