{"_buckets": {"deposit": "aa609bad-58f1-41fa-b444-499479384cb4"}, "_deposit": {"created_by": 15, "id": "81", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "81"}, "status": "published"}, "_oai": {"id": "oai:fdc.repo.nii.ac.jp:00000081", "sets": ["19"]}, "author_link": [], "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2018-03-10"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与大学", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "福岡歯科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "37114"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（歯学）"}]}, "item_10006_description_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "2017年度"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes, odontoblasts, mesothelial cells, glia cells, and others. It has been reported that podoplanin-RhoA interaction induces cytoskeleton relaxation and cell process stretching in fibroblastic cells and osteocytes, and that podoplanin plays a critical role in type I alveolar cell differentiation. It appears that podoplanin plays a number of different roles in contributing to cell functioning and growth by signaling. However, little is known about the functions of podoplanin in the somatic cells of the adult organism because an absence of podoplanin is lethal at birth by the respiratory failure. In this report, we investigated the tooth germ development in podoplanin-knockout mice, and the dentin formation in podoplanin-conditional knockout mice having neural crest-derived cells with deficiency in podoplanin by the Wnt1 promoter and enhancer-driven Cre recombinase: Wnt1-Cre;PdpnΔ/Δmice. In the Wnt1-Cre;PdpnΔ/Δmice, the tooth and alveolar bone showed no morphological abnormalities and grow normally, indicating that podoplanin is not critical in the development of the tooth and bone.", "subitem_description_type": "Abstract"}]}, "item_10006_dissertation_number_12": {"attribute_name": "報告番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第290号"}]}, "item_10006_relation_15": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "PLOS ONE"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171912", "subitem_relation_type_select": "URI"}}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takara, Kenyo"}]}, {"creatorNames": [{"creatorName": "Maruo, Naoki"}]}, {"creatorNames": [{"creatorName": "Oka, Kyoko"}]}, {"creatorNames": [{"creatorName": "Kaji, Chiaki"}]}, {"creatorNames": [{"creatorName": "Hatakeyama, Yuji"}]}, {"creatorNames": [{"creatorName": "Sawa, Naruhiko"}]}, {"creatorNames": [{"creatorName": "Kato, Yukinari"}]}, {"creatorNames": [{"creatorName": "Yamashita, Junro"}]}, {"creatorNames": [{"creatorName": "Kojima, Hiroshi"}]}, {"creatorNames": [{"creatorName": "Sawa, Yoshihiko"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-04-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "甲第290号_論文(髙良憲洋).pdf", "filesize": [{"value": "6.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 6600000.0, "url": {"label": "甲第290号_論文(髙良憲洋)", "objectType": "fulltext", "url": "https://fdc.repo.nii.ac.jp/record/81/files/甲第290号_論文(髙良憲洋).pdf"}, "version_id": "79cf4510-ca57-4a25-9a5b-379993d53f71"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-04-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "甲第290号_論文内容の要旨(髙良憲洋).pdf", "filesize": [{"value": "158.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 158100.0, "url": {"label": "甲第290号_論文内容の要旨(髙良憲洋)", "url": "https://fdc.repo.nii.ac.jp/record/81/files/甲第290号_論文内容の要旨(髙良憲洋).pdf"}, "version_id": "9ca8abc6-65e3-4ba1-b4c7-c3f4b99d715e"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-04-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "甲第290号_審査結果の要旨(髙良憲洋).pdf", "filesize": [{"value": "201.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 201900.0, "url": {"label": "甲第290号_審査結果の要旨(髙良憲洋)", "url": "https://fdc.repo.nii.ac.jp/record/81/files/甲第290号_審査結果の要旨(髙良憲洋).pdf"}, "version_id": "9d91ed63-f613-41b5-a3c9-90607d2f5753"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "ポドプラニン"}, {"subitem_subject": "川本法"}, {"subitem_subject": "コンディショナルノックアウトマウス"}, {"subitem_subject": "Wnt1"}, {"subitem_subject": "歯"}, {"subitem_subject": "Animals", "subitem_subject_language": "en"}, {"subitem_subject": "Bone and Bones", "subitem_subject_language": "en"}, {"subitem_subject": "Cells, Cultured", "subitem_subject_language": "en"}, {"subitem_subject": "Dentin", "subitem_subject_language": "en"}, {"subitem_subject": "Gene Knockout Techniques", "subitem_subject_language": "en"}, {"subitem_subject": "Genes, Reporter", "subitem_subject_language": "en"}, {"subitem_subject": "Kidney", "subitem_subject_language": "en"}, {"subitem_subject": "Membrane Glycoproteins", "subitem_subject_language": "en"}, {"subitem_subject": "Mice", "subitem_subject_language": "en"}, {"subitem_subject": "Mice, Inbred C57BL", "subitem_subject_language": "en"}, {"subitem_subject": "Mice, Knockout", "subitem_subject_language": "en"}, {"subitem_subject": "Mice, Transgenic", "subitem_subject_language": "en"}, {"subitem_subject": "Neural Crest", "subitem_subject_language": "en"}, {"subitem_subject": "Odontogenesis", "subitem_subject_language": "en"}, {"subitem_subject": "Organ Specificity", "subitem_subject_language": "en"}, {"subitem_subject": "Podocytes", "subitem_subject_language": "en"}, {"subitem_subject": "Respiratory System", "subitem_subject_language": "en"}, {"subitem_subject": "Stress, Mechanical", "subitem_subject_language": "en"}, {"subitem_subject": "Tooth Germ", "subitem_subject_language": "en"}, {"subitem_subject": "Transgenes", "subitem_subject_language": "en"}, {"subitem_subject": "podoplanin", "subitem_subject_language": "en"}, {"subitem_subject": "Kawamoto\u0027s film method", "subitem_subject_language": "en"}, {"subitem_subject": "conditional knockout mice", "subitem_subject_language": "en"}, {"subitem_subject": "Wnt1", "subitem_subject_language": "en"}, {"subitem_subject": "tooth", "subitem_subject_language": "en"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Morphological study of tooth development in podoplanin-deficient mice.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Morphological study of tooth development in podoplanin-deficient mice.", "subitem_title_language": "en"}]}, "item_type_id": "10006", "owner": "15", "path": ["19"], "permalink_uri": "https://fdc.repo.nii.ac.jp/records/81", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-04-13"}, "publish_date": "2018-04-13", "publish_status": "0", "recid": "81", "relation": {}, "relation_version_is_last": true, "title": ["Morphological study of tooth development in podoplanin-deficient mice."], "weko_shared_id": -1}