| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2015-07-06 |
| タイトル |
|
|
タイトル |
Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
diabetes |
| キーワード |
|
|
主題 |
glomerular endothelial cells |
| キーワード |
|
|
主題 |
toll-like receptor 4 |
| キーワード |
|
|
主題 |
streptozotocin |
| キーワード |
|
|
主題 |
KK/TaJcl |
| キーワード |
|
|
言語 |
en |
|
主題 |
diabetes |
| キーワード |
|
|
言語 |
en |
|
主題 |
glomerular endothelial cells |
| キーワード |
|
|
言語 |
en |
|
主題 |
toll-like receptor 4 |
| キーワード |
|
|
言語 |
en |
|
主題 |
streptozotocin |
| キーワード |
|
|
言語 |
en |
|
主題 |
KK/TaJcl |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Takata, Shunsuke
Sawa, Yoshihiko
Uchiyama, Takanobu
Ishikawa, Hiroyuki
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Diabetic conditions promote glomerulosclerosis by mesangial cells but the mechanisms are not fully elucidated. The present study evaluated the expression of toll-like receptor 4 in glomerular endothelial cells in the streptozotocin (STZ)-induced type 1 diabetic mouse (ICR-STZ) and the type 2 diabetic KK/TaJcl mouse which were fed a high fat diet feed (KK/Ta-HF). In the ICR-STZ and KK/Ta-HF almost glomeruli were immunostained with anti-TLR4 but there was no glomerulus immunostained by ani-TLR4 in the control ICR and KK/Ta. Laser-scanning confocal microscopy showed that the TLR4-positive region did not coincide with the podoplanin-positive region but coincide with the PECAM-1- and VE-cadherin-positive regions in the glomeruli of the ICR-STZ and KK/Ta-HF. The in situ hybridization showed that almost signals for TLR4 mRNA were present in the glomerulus of the ICR-STZ and KK/Ta-HF to a stronger extent than in the control ICR and KK/Ta. These suggest that glomerular endothelial cells usually express the TLR4 gene and hyperglycemia in the diabetic condition induces the TLR4 protein expression in the glomerular capillary endothelial cells. Cytokine productions through the TLR signaling pathway in glomerular endothelial cells may allow mesangial cells to produce extracellular matrix proteins in the diabetic milieu. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2014年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2015-03-14 |
| 報告番号 |
|
|
学位授与番号 |
甲第262号 |
| 情報源 |
|
|
|
関連名称 |
Acta Histochem Cytochem. 2013 Feb 28;46(1):35-42. doi: 10.1267/ahc.13002. Epub 2013 Feb 15. |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.jstage.jst.go.jp/article/ahc/46/1/46_13002/_article |
|
|
関連名称 |
J-STAGE |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第260号_論文(髙田) (1.4 MB)
