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  1. 学位論文
  2. 平成25(2013)年度
  3. 課程博士

Association of caspase-14 and filaggrin expression with keratinization of the oral mucosa and reconstruction culture rat models.

https://fdc.repo.nii.ac.jp/records/27
https://fdc.repo.nii.ac.jp/records/27
5e099574-5db1-4ec3-b5db-64200ca571d2
名前 / ファイル ライセンス アクション
甲第246号_論文(村上).pdf 甲第246号_論文(村上) (21.4 MB)
甲第246号_論文内容の要旨(村上).pdf 要旨 (86.2 kB)
甲第246号_論文審査結果の要旨(村上).pdf 審査結果の要旨 (255.4 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2014-07-15
タイトル
タイトル Association of caspase-14 and filaggrin expression with keratinization of the oral mucosa and reconstruction culture rat models.
言語 en
言語
言語 eng
キーワード
言語 en
主題 caspase-14
キーワード
言語 en
主題 filaggrin
キーワード
言語 en
主題 keratinization
キーワード
言語 en
主題 oral mucosa
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Murakami, Hiroshi

× Murakami, Hiroshi

Murakami, Hiroshi

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Okamura, Kazuhiko

× Okamura, Kazuhiko

Okamura, Kazuhiko

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Aoki, Shigehisa

× Aoki, Shigehisa

Aoki, Shigehisa

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Sakagami, Ryuji

× Sakagami, Ryuji

Sakagami, Ryuji

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Yamazaki, Jun

× Yamazaki, Jun

Yamazaki, Jun

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抄録
内容記述タイプ Abstract
内容記述 Keratinization of the oral mucosa, such as the gingiva, has been shown to be important for periodontal health. Caspase-14 is a protease that plays a role in keratinization of the epidermis. The objective of this study was to investigate whether the expression of caspase-14 is intimately linked with keratinization and to examine the effect of the main component of green tea on the improvement of keratinization in rat oral mucosal preparations.
抄録
内容記述タイプ Abstract
内容記述 Histological and immunohistochemical analyses and quantitative mRNA measurements of caspase-14 and its substrate filaggrin were performed using different types of rat epithelial tissue and organotypic reconstruction culture models derived from epithelial cells and fibroblasts taken from the rat oral mucosa.
抄録
内容記述タイプ Abstract
内容記述 In the skin, palate, buccal mucosa and esophagus, the degree of keratinization appeared to be associated with expression of cytokeratin 10. The relative protein and mRNA expression levels of caspase-14 and filaggrin were consistent with the degree of keratinization in the following order: skin > palate > buccal mucosa > esophagus. The culture models of palatal and buccal mucosa retained a stratified epithelial structure. Expression of caspase-14 appeared to be stronger in the palatal model than in the buccal model. Remarkably, epigallocatechin-3-gallate (EGCG) improved the localization of cytokeratins and increased the expression of caspase-14 and filaggrin. This expression was more intense in the palatal model than in the buccal model, indicating that both models maintain the intrinsic properties of keratinization of the mucosa from where the cultured cells were derived.
抄録
内容記述タイプ Abstract
内容記述 These results suggest that keratinization is closely associated with expression of caspase-14 and filaggrin. Our reconstruction models are promising tools for drug evaluation and show that EGCG is beneficial for improving both keratinization and expression of the linked protease in the oral mucosa.
学位名
学位名 博士(歯学)
学位授与大学
学位授与機関識別子 37114
学位授与機関名 福岡歯科大学
学位授与年度
内容記述 2013年度
学位授与年月日
学位授与年月日 2014-03-15
報告番号
学位授与番号 甲第246号
情報源
関連名称 J Periodontal Res. 2013 Dec 11. doi: 10.1111/jre.12152.
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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