| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2014-05-08 |
| タイトル |
|
|
タイトル |
Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
diabetes |
| キーワード |
|
|
言語 |
en |
|
主題 |
kidney |
| キーワード |
|
|
言語 |
en |
|
主題 |
lymphangiogenesis |
| キーワード |
|
|
言語 |
en |
|
主題 |
lymphatics |
| キーワード |
|
|
言語 |
en |
|
主題 |
nephropathy |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Uchiyama, Takanobu
Takata, Shunsuke
Ishikawa, Hiroyuki
Sawa, Yoshihiko
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The dynamics of the renal lymphatic circulation in diabetic nephropathy is not fully elucidated. The present study evaluated the effect of diabetic nephropathy on the renal lymphatic circulation in streptozotocin (STZ)-induced type 1 diabetic mice (ICR-STZ) and in type 2 diabetic KK/Ta mice which were fed a high fat diet (KK/Ta-HF). The diabetic mouse kidneys developed edema because of the nephropathy. In control mice renal lymphatic vessels distributed in the cortex but rarely in the medulla while in ICR-STZ and KK/Ta-HF mice, there were many lymphatic vessels with small lumen in both cortex and medulla. Total numbers and areas of renal blood vessels in the diabetic mice were similar to those in the controls while the total numbers and areas of renal lymphatic vessels were larger in diabetic mice than in the controls. There were statistically significant differences in the numbers of lymphatic vessels with diameters of 50-100 µm between the ICR-STZ and the control ICR mice, and in the numbers of lymphatic capillaries with diameters smaller than 50 µm between the KK/Ta-HF and the control KK/Ta mice. The diabetic nephropathy may induce the lymphangiogenesis or result in at least the renal lymphatic vessel expansion. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2013年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2014-03-15 |
| 報告番号 |
|
|
学位授与番号 |
甲第248号 |
| 権利 |
|
|
権利情報 |
著作権は日本組織細胞化学会が所有 |
| 情報源 |
|
|
|
関連名称 |
Acta Histochem Cytochem. 2013 Apr 30;46(2):97-104. doi: 10.1267/ahc.13006. Epub 2013 Apr 12. |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.jstage.jst.go.jp/article/ahc/46/2/46_13006/_article |
|
|
関連名称 |
J-STAGE |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第248号_論文(内山) (1.1 MB)
