| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2014-04-28 |
| タイトル |
|
|
タイトル |
Distribution of podoplanin-expressing cells in the mouse nervous systems. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
podoplanin |
| キーワード |
|
|
言語 |
en |
|
主題 |
nervous system |
| キーワード |
|
|
言語 |
en |
|
主題 |
glia cell |
| キーワード |
|
|
言語 |
en |
|
主題 |
astrocyte |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Tomooka, Miwa
Kaji, Chiaki
Kojima, Hiroshi
Sawa, Yoshihiko
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Podoplanin is a mucin-type glycoprotein which was first identified in podocytes. Recently, podoplanin has been successively reported as a marker for brain and peripheral nerve tumors, however, the distribution of podoplanin-expressing cells in normal nerves has not been fully investigated. This study aims to examine the podoplanin-expressing cell distribution in the mouse head and nervous systems. An immunohistochemical study showed that the podoplanin-positive areas in the mouse peripheral nerve and spinal cord are perineurial fibroblasts, satellite cells in the dorsal root ganglion, glia cells in the ventral and dorsal horns, and schwann cells in the ventral and dorsal roots; in the cranial meninges the dura mater, arachnoid, and pia mater; in the eye the optic nerve, retinal pigment epithelium, chorioidea, sclera, iris, lens epithelium, corneal epithelium, and conjunctival epithelium. In the mouse brain choroid plexus and ependyma were podoplanin-positive, and there were podoplanin-expressing brain parenchymal cells in the nuclei and cortex. The podoplanin-expressing cells were astrocyte marker GFAP-positive and there were no differences in the double positive cell distribution of several portions in the brain parenchyma except for the fornix. The results suggest that podoplanin may play a common role in nervous system support cells and eye constituents. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与大学 |
|
|
|
学位授与機関識別子 |
37114 |
|
|
学位授与機関名 |
福岡歯科大学 |
| 学位授与年度 |
|
|
内容記述 |
2013年度 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2014-03-15 |
| 報告番号 |
|
|
学位授与番号 |
甲第250号 |
| 権利 |
|
|
権利情報 |
著作権は日本組織細胞化学会が所有する |
| 情報源 |
|
|
|
関連名称 |
Acta Histochem Cytochem. 2013 Dec 28;46(6):171-7. doi: 10.1267/ahc.13035. Epub 2013 Dec 25. |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.jstage.jst.go.jp/article/ahc/46/6/46_13035/_article |
|
|
関連名称 |
J-STAGE |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
甲第250号_論文(友岡) (1.5 MB)
