{"created":"2023-05-15T09:58:09.023502+00:00","id":53,"links":{},"metadata":{"_buckets":{"deposit":"90ff4405-f110-45d4-bcc9-a0ab83e94032"},"_deposit":{"created_by":15,"id":"53","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"53"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000053","sets":["1:11:12"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-12"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学） "}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2015年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The ciliary zonule in the eye, also known as Zinn's zonule, is composed of oxytalan fibers, which are bundles of microfibrils consisting mainly of fibrillin-1. However, it is still unclear which of the microfibril-associated molecules present in the ciliary zonule controls oxytalan fibers. Microfibril-associated glycoprotein-1 (MAGP-1) is the only microfibril-associated molecule identified in the human ciliary zonule. In the present study, we used siRNA against MAGP-1 in cultures of human non-pigmented ciliary epithelial cells to examine the extracellular deposition and appearance of fibrillin-1 employing Western blotting and immunofluorescence. MAGP-1 suppression led to a reduction of fibrillin-1 deposition. Immunofluorescence also confirmed that RNAi-mediated down-regulation of MAGP-1 led to suppression of fiber development. These results suggest that MAGP-1 plays a crucial role in the extracellular deposition of fibrillin-1 during formation of the human ciliary zonule.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第271号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Acta Histochem Cytochem. 2014 Feb 27;47(1):11-7. doi: 10.1267/ahc.13038. Epub 2014 Feb 18."}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"J-STAGE"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/ahc/47/1/47_13038/_article","subitem_relation_type_select":"URI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Takahiro"}]},{"creatorNames":[{"creatorName":"Tsuruga, Eichi"}]},{"creatorNames":[{"creatorName":"Yamanouchi, Kaori"}]},{"creatorNames":[{"creatorName":"Sawa, Yoshihiko"}]},{"creatorNames":[{"creatorName":"Ishikawa, Hiroyuki"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-22"}],"displaytype":"detail","filename":"甲第271号_論文(藤田).pdf","filesize":[{"value":"884.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第271号_論文(藤田)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/53/files/甲第271号_論文(藤田).pdf"},"version_id":"56c20fa3-f5ee-48d5-9c03-1f1d0a20d873"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-22"}],"displaytype":"detail","filename":"甲第271号_論文内容の要旨(藤田).pdf","filesize":[{"value":"82.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://fdc.repo.nii.ac.jp/record/53/files/甲第271号_論文内容の要旨(藤田).pdf"},"version_id":"dcbf57cc-0da6-4be3-9ae9-03087e9d95b1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-22"}],"displaytype":"detail","filename":"甲第271号_論文審査結果の要旨(藤田).pdf","filesize":[{"value":"116.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果の要旨","url":"https://fdc.repo.nii.ac.jp/record/53/files/甲第271号_論文審査結果の要旨(藤田).pdf"},"version_id":"df959e2f-d328-4c6c-a444-0ab65a1b97f9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"fibrillin"},{"subitem_subject":"MAGP-1"},{"subitem_subject":"微細線維"},{"subitem_subject":"オキシタラン線維"},{"subitem_subject":"毛様体小帯"},{"subitem_subject":"fibrillin","subitem_subject_language":"en"},{"subitem_subject":"MAGP-1","subitem_subject_language":"en"},{"subitem_subject":"microfibrils","subitem_subject_language":"en"},{"subitem_subject":"oxytalan fibers","subitem_subject_language":"en"},{"subitem_subject":"ciliary zonule","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["12"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-04-22"},"publish_date":"2016-04-22","publish_status":"0","recid":"53","relation_version_is_last":true,"title":["Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T02:00:26.244241+00:00"}