@phdthesis{oai:fdc.repo.nii.ac.jp:00000053,
 author = {Fujita, Takahiro and Tsuruga, Eichi and Yamanouchi, Kaori and Sawa, Yoshihiko and Ishikawa, Hiroyuki},
 month = {2016-04-22, 2016-04-22, 2016-04-22},
 note = {2015年度, The ciliary zonule in the eye, also known as Zinn's zonule, is composed of oxytalan fibers, which are bundles of microfibrils consisting mainly of fibrillin-1. However, it is still unclear which of the microfibril-associated molecules present in the ciliary zonule controls oxytalan fibers. Microfibril-associated glycoprotein-1 (MAGP-1) is the only microfibril-associated molecule identified in the human ciliary zonule. In the present study, we used siRNA against MAGP-1 in cultures of human non-pigmented ciliary epithelial cells to examine the extracellular deposition and appearance of fibrillin-1 employing Western blotting and immunofluorescence. MAGP-1 suppression led to a reduction of fibrillin-1 deposition. Immunofluorescence also confirmed that RNAi-mediated down-regulation of MAGP-1 led to suppression of fiber development. These results suggest that MAGP-1 plays a crucial role in the extracellular deposition of fibrillin-1 during formation of the human ciliary zonule.},
 school = {福岡歯科大学},
 title = {Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro.},
 year = {}
}