{"created":"2023-05-15T09:58:08.935969+00:00","id":50,"links":{},"metadata":{"_buckets":{"deposit":"997739a2-46f6-4a02-b19a-b79582709427"},"_deposit":{"created_by":15,"id":"50","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"50"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000050","sets":["1:11:12"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-12"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学 "}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2015年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND:\nAdministration of mercury at nontoxic doses induces systemic autoimmune disease in Brown Norway (BN) rats. The pathogenesis of lupus-like oral mucosal lesion by mercury-induced autoimmunity is still unclear, even though the oral mucosa is observed to be commonly affected in mercury-treated BN rats. In this study, we investigated the immunopathology of lupus-like oral mucosal lesions in a model of mercury-induced systemic autoimmunity.\n\nMETHODS:\nBrown Norway male rats were injected subcutaneously with either phosphate-buffered saline (control) or mercury at a dose of 1.0 mg per kilogram of body weight on days 0, 3, 5, and 7. Blood, kidney, and tongue samples were taken at various timepoints for evaluation by immunohistochemistry, RT-PCR, and lupus band test (LBT).\n\nRESULTS:\nOral mucosal lesions were classified according to three consecutive temporal phases on the basis of infiltration of immunocompetent cells as follows: (phase I) infiltration of MHC class II+ dendritic cells (DC) and macrophages; (phase II) addition of ED1+ macrophage infiltrates; and (phase III) focal infiltration of pan T cells following increased infiltration of DC and macrophages. Dense infiltration of DC and macrophages was observed in the basement membrane (BM) zone of the oral epithelium. Tissue expression of IL-4 mRNA was detected in early lesions (phase I), suggesting that locally produced IL-4 may be responsible for Th2-mediated immune response. A linear and continuous smooth pattern of fluorescence was observed in the oral epithelial BM in addition to renal glomeruli, indicating immune complex deposits.\n\nCONCLUSIONS:\nLocal autoimmune responses are involved in the pathogenesis of mercury-induced lupus-like lesions of the oral mucosa.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第273号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"BMC Immunol. 2013 Oct 3;14:47. doi: 10.1186/1471-2172-14-47."}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"BioMed Central"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-14-47","subitem_relation_type_select":"URI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Seno, Kei"}]},{"creatorNames":[{"creatorName":"Ohno, Jun"}]},{"creatorNames":[{"creatorName":"Ota, Nobutaka"}]},{"creatorNames":[{"creatorName":"Hirofuji, Takao"}]},{"creatorNames":[{"creatorName":"Taniguchi, Kunihisa"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-04"}],"displaytype":"detail","filename":"甲第273号_論文(瀨野).pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第273号_論文(瀨野)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/50/files/甲第273号_論文(瀨野).pdf"},"version_id":"0fbf01e3-f487-4576-9103-5178a7d5beb2"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-04"}],"displaytype":"detail","filename":"甲第273号_論文内容の要旨(瀨野).pdf","filesize":[{"value":"87.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://fdc.repo.nii.ac.jp/record/50/files/甲第273号_論文内容の要旨(瀨野).pdf"},"version_id":"602a9f82-3bbb-4fcc-ba7c-3eec37aa13a3"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-04"}],"displaytype":"detail","filename":"甲第273号_論文審査結果の要旨(瀨野).pdf","filesize":[{"value":"90.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果の要旨","url":"https://fdc.repo.nii.ac.jp/record/50/files/甲第273号_論文審査結果の要旨(瀨野).pdf"},"version_id":"dd2c2336-e9eb-41f1-a79d-b25df14fadf4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"水銀誘導型自己免疫応答"},{"subitem_subject":"口腔粘膜"},{"subitem_subject":"ループス様病変"},{"subitem_subject":"Brown Norwayラット"},{"subitem_subject":"マクロファージ"},{"subitem_subject":"Animals","subitem_subject_language":"en"},{"subitem_subject":"Antigens, CD5","subitem_subject_language":"en"},{"subitem_subject":"Autoimmune Diseases","subitem_subject_language":"en"},{"subitem_subject":"Autoimmunity","subitem_subject_language":"en"},{"subitem_subject":"Basement Membrane","subitem_subject_language":"en"},{"subitem_subject":"Dendritic Cells","subitem_subject_language":"en"},{"subitem_subject":"Epithelium","subitem_subject_language":"en"},{"subitem_subject":"Gene Expression","subitem_subject_language":"en"},{"subitem_subject":"Histocompatibility Antigens Class II","subitem_subject_language":"en"},{"subitem_subject":"Immunohistochemistry","subitem_subject_language":"en"},{"subitem_subject":"Injections, Subcutaneous","subitem_subject_language":"en"},{"subitem_subject":"Interferon-gamma","subitem_subject_language":"en"},{"subitem_subject":"Interleukin-4","subitem_subject_language":"en"},{"subitem_subject":"Kidney","subitem_subject_language":"en"},{"subitem_subject":"Macrophages","subitem_subject_language":"en"},{"subitem_subject":"Male","subitem_subject_language":"en"},{"subitem_subject":"Mercury","subitem_subject_language":"en"},{"subitem_subject":"Mouth Mucosa","subitem_subject_language":"en"},{"subitem_subject":"Rats","subitem_subject_language":"en"},{"subitem_subject":"Rats, Inbred BN","subitem_subject_language":"en"},{"subitem_subject":"Reverse Transcriptase Polymerase Chain Reaction","subitem_subject_language":"en"},{"subitem_subject":"T-Lymphocytes","subitem_subject_language":"en"},{"subitem_subject":"Time Factors","subitem_subject_language":"en"},{"subitem_subject":"Tongue","subitem_subject_language":"en"},{"subitem_subject":"Mercury-induced autoimmunity","subitem_subject_language":"en"},{"subitem_subject":"Oral mucosa","subitem_subject_language":"en"},{"subitem_subject":"Lupus-like lesions","subitem_subject_language":"en"},{"subitem_subject":"Brown Norway rats","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Lupus-like oral mucosal lesions in mercury-induced autoimmune response in Brown Norway rats.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Lupus-like oral mucosal lesions in mercury-induced autoimmune response in Brown Norway rats.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["12"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-04-04"},"publish_date":"2016-04-04","publish_status":"0","recid":"50","relation_version_is_last":true,"title":["Lupus-like oral mucosal lesions in mercury-induced autoimmune response in Brown Norway rats."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T02:00:24.306086+00:00"}