{"created":"2023-05-15T09:58:08.503472+00:00","id":40,"links":{},"metadata":{"_buckets":{"deposit":"6a481b5f-56c1-475f-baa3-c549173164c7"},"_deposit":{"created_by":15,"id":"40","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"40"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000040","sets":["1:7:8"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-14"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2014年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The bone regenerative healing process is often prolonged, with a high risk of infection particularly in elderly and diseased patients. A reduction in healing process time usually requires mechanical stress devices, chemical cues, or laser/thermal therapies. Although these approaches have been used extensively for the reduction of bone healing time, the exact mechanisms involved in thermal stress-induced bone regeneration remain unclear. In this study, we investigated the effect of optimal hyperthermia on rat calvarial defects in vivo and on osteogenesis in vitro. Photothermal stress stimulation was carried out using a new photothermal device, composed of an alginate gel including in carbon nanotubes and their irradiator with near-infrared light. Photothermal stress (15 min at 42℃, every day), trigged by near-infrared-induced carbon nanotube, promoted bone deposition in critical-sized calvarial defects compared with nonthermal stress controls. We recently reported that our novel DNA/protamine complex scaffold induces bone regeneration in calvarial defects. In this study, photothermal stress upregulated bone deposition in DNA/protamine-engrafted calvarial defects. Furthermore, photothermal stress significantly induced expression of osteogenic related genes in a time-dependent manner, including alkaline phosphatase, osterix, and osteocalcin. This was observed in DNA/protamine cells, which were expanded from regenerated tissue engrafted into the DNA/protamine scaffold, as well as in human MG63 preosteoblasts. In summary, this novel carbon nanotube-based photothermal stress approach upregulated expression of osteogenic-related genes in preosteoblasts, resulting in promotion of mineral deposition for enhanced bone repair.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第260号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"J Biomater Appl. 2015 Mar;29(8):1109-18. doi: 10.1177/0885328214556913. Epub 2014 Oct 20."}]}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yanagi, Tsukasa"}]},{"creatorNames":[{"creatorName":"Kajiya, Hiroshi"}]},{"creatorNames":[{"creatorName":"Kawaguchi, Minoru"}]},{"creatorNames":[{"creatorName":"Kido, Hirofumi"}]},{"creatorNames":[{"creatorName":"Fukushima, Tadao"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-27"}],"displaytype":"detail","filename":"甲第260号_論文(柳).pdf","filesize":[{"value":"2.1 MB"}],"format":"binary/octet-stream","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第260号_論文(柳)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/40/files/甲第260号_論文(柳).pdf"},"version_id":"6037998f-bfed-4e1a-b1fd-5b22fb2a9657"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-27"}],"displaytype":"detail","filename":"甲第260号_論文内容の要旨(柳).pdf","filesize":[{"value":"306.4 kB"}],"format":"binary/octet-stream","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://fdc.repo.nii.ac.jp/record/40/files/甲第260号_論文内容の要旨(柳).pdf"},"version_id":"f5f1773f-e25e-4893-9246-a9f4b15761d3"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-27"}],"displaytype":"detail","filename":"甲第260号_論文審査結果の要旨(柳).pdf","filesize":[{"value":"250.7 kB"}],"format":"binary/octet-stream","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果の要旨","url":"https://fdc.repo.nii.ac.jp/record/40/files/甲第260号_論文審査結果の要旨(柳).pdf"},"version_id":"c25f70c7-4063-46bd-8555-13d76d323c6b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"温熱刺激"},{"subitem_subject":"カーボンナノチューブ"},{"subitem_subject":"近赤外線"},{"subitem_subject":"DNA/プロタミン複合体"},{"subitem_subject":"骨形成"},{"subitem_subject":"Photothermal stress","subitem_subject_language":"en"},{"subitem_subject":"Carbon nano tubes","subitem_subject_language":"en"},{"subitem_subject":"Near infrared ray","subitem_subject_language":"en"},{"subitem_subject":"DNA/Protamine complex","subitem_subject_language":"en"},{"subitem_subject":"Osteogenesis","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Photothermal stress triggered by near infrared-irradiated carbon nanotubes promotes bone deposition in rat calvarial defects.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Photothermal stress triggered by near infrared-irradiated carbon nanotubes promotes bone deposition in rat calvarial defects.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["8"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-03-27"},"publish_date":"2015-03-27","publish_status":"0","recid":"40","relation_version_is_last":true,"title":["Photothermal stress triggered by near infrared-irradiated carbon nanotubes promotes bone deposition in rat calvarial defects."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-11T01:22:02.165252+00:00"}