{"created":"2023-05-15T09:58:08.436863+00:00","id":39,"links":{},"metadata":{"_buckets":{"deposit":"bdec5244-23dc-4abd-878b-7ef9fd0a461c"},"_deposit":{"created_by":15,"id":"39","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"39"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000039","sets":["1:3:6"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-15"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aldehyde dehydrogenase isoform 1 (ALDH1) is a useful marker of cancer-initiating cells (CICs) in various organs. In this study, we investigated whether alterations in ALDH1 immunostaining and enzymatic activity in tumor cell populations predicted clinicopathological factors of prognostic importance for cancer progression and contributed to the characteristics of CICs in cisplatin-treated oral squamous cell cancer (OSCC) cells. We evaluated the association between the proportion of ALDH1-positive tumor cells and the clinicopathological features in 90 patients with OSCC. We also examined ALDH1 enzymatic activity, ABCG2 expression, invasive capacity and the ability to self-renew in OSCC cells treated with or without cisplatin. The clinicopathological results showed that elevated ALDH1 expression correlated with local recurrence. In in vitro experiments, the percentage of cells exhibiting ALDH1 enzymatic activity significantly increased among cisplatin-surviving cells (CiSCs) according to flow cytometry. Furthermore, CiSCs demonstrated upregulated expression of ABCG2, their invasive capacity increased, and their ability to generate cancer spheres was enhanced. An increased population of cells exhibiting ALDH1 immunostaining is a predictive marker of local recurrence. ALDH1 expression and activity contributes to the characteristics of CICs in OSCC.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第256号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Int J Oncol. 2014 Feb;44(2):435-42. doi: 10.3892/ijo.2013.2188. Epub 2013 Nov 27."}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":" International Journal of Oncology"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.spandidos-publications.com/ijo/44/2/435","subitem_relation_type_select":"URI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ota, Nobutaka"}]},{"creatorNames":[{"creatorName":"Ohno, Jun"}]},{"creatorNames":[{"creatorName":"Seno, Kei"}]},{"creatorNames":[{"creatorName":"Taniguchi, Kunihisa"}]},{"creatorNames":[{"creatorName":"Ozeki, Satoru"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-24"}],"displaytype":"detail","filename":"甲第256号_論文(太田).pdf","filesize":[{"value":"665.2 kB"}],"format":"binary/octet-stream","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第256号_論文(太田)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/39/files/甲第256号_論文(太田).pdf"},"version_id":"dc050acd-fad3-4cf3-9ba1-815ba5f33784"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-24"}],"displaytype":"detail","filename":"甲第256号_論文内容の要旨(太田).pdf","filesize":[{"value":"86.9 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cell","subitem_subject_language":"en"},{"subitem_subject":"Aged","subitem_subject_language":"en"},{"subitem_subject":"Aged, 80 and over","subitem_subject_language":"en"},{"subitem_subject":"Antineoplastic Agents","subitem_subject_language":"en"},{"subitem_subject":"Blotting, Western","subitem_subject_language":"en"},{"subitem_subject":"Carcinoma, Squamous Cell","subitem_subject_language":"en"},{"subitem_subject":"Cell Movement","subitem_subject_language":"en"},{"subitem_subject":"Cell Proliferation","subitem_subject_language":"en"},{"subitem_subject":"Cisplatin","subitem_subject_language":"en"},{"subitem_subject":"Drug Resistance, Neoplasm","subitem_subject_language":"en"},{"subitem_subject":"Female","subitem_subject_language":"en"},{"subitem_subject":"Humans","subitem_subject_language":"en"},{"subitem_subject":"Immunoenzyme Techniques","subitem_subject_language":"en"},{"subitem_subject":"In Vitro Techniques","subitem_subject_language":"en"},{"subitem_subject":"Isoenzymes","subitem_subject_language":"en"},{"subitem_subject":"Male","subitem_subject_language":"en"},{"subitem_subject":"Middle Aged","subitem_subject_language":"en"},{"subitem_subject":"Mouth Neoplasms","subitem_subject_language":"en"},{"subitem_subject":"Neoplasm Recurrence, Local","subitem_subject_language":"en"},{"subitem_subject":"Neoplasm Staging","subitem_subject_language":"en"},{"subitem_subject":"Prognosis","subitem_subject_language":"en"},{"subitem_subject":"Retinal Dehydrogenase","subitem_subject_language":"en"},{"subitem_subject":"Tumor Cells, Cultured","subitem_subject_language":"en"},{"subitem_subject":"Tumor Markers, Biological","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["6"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-03-24"},"publish_date":"2015-03-24","publish_status":"0","recid":"39","relation_version_is_last":true,"title":["In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T01:55:27.971574+00:00"}