{"created":"2023-05-15T09:58:08.370435+00:00","id":38,"links":{},"metadata":{"_buckets":{"deposit":"f3f8f41a-bda2-45a2-ba5c-f64db7bb6d03"},"_deposit":{"created_by":15,"id":"38","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"38"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000038","sets":["1:7:9"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-14"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2014年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To evaluate the effects of the lactic acid bacterium Lactobacillus salivarius on caries risk factors.","subitem_description_type":"Abstract"},{"subitem_description":"The study was performed in 64 healthy volunteers to evaluate the effects of L. salivarius-containing tablets on caries risk factors. The participants were divided randomly into four groups, and took tablets containing L. salivarius WB21, L. salivarius TI 2711, Ovalgen® DC (antibody against glucosyltransferase from Streptococcus mutans), or xylitol. Levels of mutans streptococci and lactobacilli, amount of salivary flow, salivary pH, and salivary buffering capacity were assessed before and after taking the tablets. Subsequently, a short-term administration trial using L. salivarius WB21-containing tablets was performed in eight healthy volunteers. The participants took L. salivarius WB21-containing tablets (2.0 × 10(9) colony forming units/day) for 2 weeks, and the numbers of mutans streptococci in saliva were counted.","subitem_description_type":"Abstract"},{"subitem_description":"The levels of mutans streptococci seemed to decrease in the L. salivarius WB21, TI 2711, and Ovalgen® DC groups compared to the xylitol group, with no significant differences between the groups. Lactobacilli levels significantly increased in the L. salivarius WB21 and TI 2711 groups compared to the other groups. Concerning salivary flow and salivary pH, no significant differences were observed between the groups. The salivary buffering capacity significantly increased in the L. salivarius TI 2711 group (P = 0.003) and Ovalgen® DC group (P = 0.002) compared to the xylitol group. The short-term administration trial showed that the L. salivarius WB21-containing tablets significantly decreased the number of mutans streptococci (P = 0.039).","subitem_description_type":"Abstract"},{"subitem_description":"L. salivarius-containing tablets were suggested to increase resistance to caries risk factors.","subitem_description_type":"Abstract"},{"subitem_description":"UMIN000013160 (registration date: February 14, 2014).","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第93号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"BMC Oral Health. 2014 Sep 2;14:110. doi: 10.1186/1472-6831-14-110."}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Bio Med Central"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.biomedcentral.com/1472-6831/14/110","subitem_relation_type_select":"URI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishihara, Tetsuyo"}]},{"creatorNames":[{"creatorName":"Suzuki, Nao"}]},{"creatorNames":[{"creatorName":"Yoneda, Masahiro"}]},{"creatorNames":[{"creatorName":"Hirofuji, Takao"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-23"}],"displaytype":"detail","filename":"乙第93号_論文(西原).pdf","filesize":[{"value":"222.7 kB"}],"format":"binary/octet-stream","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"乙第93号_論文(西原)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/38/files/乙第93号_論文(西原).pdf"},"version_id":"a810a16a-056f-488b-844b-ad1c65911d7b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-23"}],"displaytype":"detail","filename":"乙第93号_論文内容の要旨(西原).pdf","filesize":[{"value":"271.6 kB"}],"format":"binary/octet-stream","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://fdc.repo.nii.ac.jp/record/38/files/乙第93号_論文内容の要旨(西原).pdf"},"version_id":"cf814e24-8577-4119-8f93-c0095f4853dc"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-23"}],"displaytype":"detail","filename":"乙第93号_論文審査結果の要旨(西原).pdf","filesize":[{"value":"262.7 kB"}],"format":"binary/octet-stream","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果の要旨","url":"https://fdc.repo.nii.ac.jp/record/38/files/乙第93号_論文審査結果の要旨(西原).pdf"},"version_id":"27991f94-22b3-442d-8ba0-6890e118ccc3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"う蝕リスク因子"},{"subitem_subject":"プロバイオティクス"},{"subitem_subject":"ラクトバチルスサリバリウス"},{"subitem_subject":"ミュータンスレンサ球菌"},{"subitem_subject":"口腔内環境"},{"subitem_subject":"Caries risk factor","subitem_subject_language":"en"},{"subitem_subject":"Lactobacillus salivarius","subitem_subject_language":"en"},{"subitem_subject":"Mutans streptococci","subitem_subject_language":"en"},{"subitem_subject":"Oral environment","subitem_subject_language":"en"},{"subitem_subject":"Adult","subitem_subject_language":"en"},{"subitem_subject":"Antibodies","subitem_subject_language":"en"},{"subitem_subject":"Bacterial Load","subitem_subject_language":"en"},{"subitem_subject":"Buffers","subitem_subject_language":"en"},{"subitem_subject":"Cariostatic Agents","subitem_subject_language":"en"},{"subitem_subject":"Dental Caries","subitem_subject_language":"en"},{"subitem_subject":"Dental Caries Susceptibility","subitem_subject_language":"en"},{"subitem_subject":"Female","subitem_subject_language":"en"},{"subitem_subject":"Glucosyltransferases","subitem_subject_language":"en"},{"subitem_subject":"Humans","subitem_subject_language":"en"},{"subitem_subject":"Hydrogen-Ion Concentration","subitem_subject_language":"en"},{"subitem_subject":"Lactobacillus","subitem_subject_language":"en"},{"subitem_subject":"Male","subitem_subject_language":"en"},{"subitem_subject":"Microbial Interactions","subitem_subject_language":"en"},{"subitem_subject":"Probiotics","subitem_subject_language":"en"},{"subitem_subject":"Risk Factors","subitem_subject_language":"en"},{"subitem_subject":"Saliva","subitem_subject_language":"en"},{"subitem_subject":"Secretory Rate","subitem_subject_language":"en"},{"subitem_subject":"Streptococcus mutans","subitem_subject_language":"en"},{"subitem_subject":"Tablets","subitem_subject_language":"en"},{"subitem_subject":"Xylitol","subitem_subject_language":"en"},{"subitem_subject":"Young Adult","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of Lactobacillus salivarius-containing tablets on caries risk factors: a randomized open-label clinical trial.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Lactobacillus salivarius-containing tablets on caries risk factors: a randomized open-label clinical trial.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-03-23"},"publish_date":"2015-03-23","publish_status":"0","recid":"38","relation_version_is_last":true,"title":["Effects of Lactobacillus salivarius-containing tablets on caries risk factors: a randomized open-label clinical trial."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T01:58:55.787666+00:00"}