{"created":"2023-05-15T09:58:07.857974+00:00","id":25,"links":{},"metadata":{"_buckets":{"deposit":"f8cc3a2d-4657-4e87-93d3-995cb3930ea5"},"_deposit":{"created_by":15,"id":"25","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"25"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000025","sets":["1:3:6"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-15"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We have recently reported that MS induces predominantly C-C chemokine ligand (CCL) 2 expression in PDL tissues, leading, via C-C chemokine receptor (CCR) 2, to MS-dependent osteoclastogenesis in alveolar bone. Thus, we hypothesize that ablation of the CCL2/CCR2 signaling pathway should suppress MS-induced osteoclastogenesis-associated chemokines and alleviate occlusal traumatism. We examined the effect of MS on chemokine expression and osteoclastogenesis using in vivo and in vitro hyperocclusion models with CCL2-deficient (CCL2((-/-))) and CCR2-deficient (CCR2((-/-))) mice. Compared with that in wild-type mice, expression of CCL3 in PDL cells and TRAP-positive cells in alveolar bone from CCL2((-/-)) and CCR2((-/-)) mice was up-regulated, even in the absence of MS. Furthermore, the expression of CCL3 and TRAP-positive cells was significantly increased after both 4 and 7 days of hyperocclusal MS loading in CCL2((-/-)) and CCR2((-/-)) mice. Hyperocclusion induced compensatory CCL3 expression and promoted osteoclastogenesis to counterbalance deficient CCL2/CCR2 signaling, suggesting that co-expression of CCL3 with CCL2 may precipitate synergistic, MS-dependent alveolar bone destruction during occlusal traumatism.Abbreviations: MS, mechanical stress; PDL, periodontal ligament; CCL2, CC chemokine ligand 2 (MCP-1; monocyte chemoattractant protein-1); CCR2, CC chemokine receptor 2; CCL3, CC chemokine ligand 3 (MIP-1α); CCL5, CC chemokine ligand 5 (RANTES).","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第243号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"J Dent Res. 2013 Jan;92(1):65-70. doi: 10.1177/0022034512467803. Epub 2012 Nov 9."}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"JDR"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://jdr.sagepub.com/content/92/1/65.long","subitem_relation_type_select":"URI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsutsumi, Takashi"}]},{"creatorNames":[{"creatorName":"Kajiya, Hiroshi"}]},{"creatorNames":[{"creatorName":"Goto, Kazuko"}]},{"creatorNames":[{"creatorName":"Takahashi, Yutaka"}]},{"creatorNames":[{"creatorName":"Okabe, Koji"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-06-18"}],"displaytype":"detail","filename":"甲第243号_論文(堤).pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"甲第243号_論文(堤)","objectType":"fulltext","url":"https://fdc.repo.nii.ac.jp/record/25/files/甲第243号_論文(堤).pdf"},"version_id":"72d53a27-5d02-4c72-85d2-f40b35d727ea"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-06-18"}],"displaytype":"detail","filename":"甲第243号_論文内容の要旨(堤).pdf","filesize":[{"value":"80.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://fdc.repo.nii.ac.jp/record/25/files/甲第243号_論文内容の要旨(堤).pdf"},"version_id":"d499a392-9618-44a7-99cd-1f9d51cd5d96"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-06-18"}],"displaytype":"detail","filename":"甲第243号_論文審査結果の要旨(堤).pdf","filesize":[{"value":"288.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果の要旨","url":"https://fdc.repo.nii.ac.jp/record/25/files/甲第243号_論文審査結果の要旨(堤).pdf"},"version_id":"37882830-fa11-4db8-8fd9-2762fca548dd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"traumatic dental occlusion","subitem_subject_language":"en"},{"subitem_subject":"mechanical stress","subitem_subject_language":"en"},{"subitem_subject":"bone resorption","subitem_subject_language":"en"},{"subitem_subject":"Acid Phosphatase","subitem_subject_language":"en"},{"subitem_subject":"Alveolar Bone Loss","subitem_subject_language":"en"},{"subitem_subject":"Alveolar Process","subitem_subject_language":"en"},{"subitem_subject":"Animals","subitem_subject_language":"en"},{"subitem_subject":"Biomechanical Phenomena","subitem_subject_language":"en"},{"subitem_subject":"Cell Culture Techniques","subitem_subject_language":"en"},{"subitem_subject":"Chemokine CCL2","subitem_subject_language":"en"},{"subitem_subject":"Chemokine CCL3","subitem_subject_language":"en"},{"subitem_subject":"Chemokine CCL5","subitem_subject_language":"en"},{"subitem_subject":"Dental Occlusion, Traumatic","subitem_subject_language":"en"},{"subitem_subject":"Isoenzymes","subitem_subject_language":"en"},{"subitem_subject":"Malocclusion","subitem_subject_language":"en"},{"subitem_subject":"Mice","subitem_subject_language":"en"},{"subitem_subject":"Mice, Inbred C57BL","subitem_subject_language":"en"},{"subitem_subject":"Mice, Knockout","subitem_subject_language":"en"},{"subitem_subject":"Osteoclasts","subitem_subject_language":"en"},{"subitem_subject":"Periodontal Ligament","subitem_subject_language":"en"},{"subitem_subject":"Receptors, CCR1","subitem_subject_language":"en"},{"subitem_subject":"Receptors, CCR2","subitem_subject_language":"en"},{"subitem_subject":"Signal Transduction","subitem_subject_language":"en"},{"subitem_subject":"Stress, Mechanical","subitem_subject_language":"en"},{"subitem_subject":"Time Factors","subitem_subject_language":"en"},{"subitem_subject":"Up-Regulation","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Hyperocclusion up-regulates CCL3 expression in CCL2- and CCR2-deficient mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hyperocclusion up-regulates CCL3 expression in CCL2- and CCR2-deficient mice.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["6"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-06-18"},"publish_date":"2014-06-18","publish_status":"0","recid":"25","relation_version_is_last":true,"title":["Hyperocclusion up-regulates CCL3 expression in CCL2- and CCR2-deficient mice."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T01:55:16.913996+00:00"}