{"created":"2023-05-15T09:58:10.992237+00:00","id":109,"links":{},"metadata":{"_buckets":{"deposit":"7c5772c5-5735-4014-b2e7-e738d4ff4e8c"},"_deposit":{"created_by":15,"id":"109","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"109"},"status":"published"},"_oai":{"id":"oai:fdc.repo.nii.ac.jp:00000109","sets":["1:23:24"]},"author_link":[],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-30"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"福岡歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37114"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":" 博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2019年度"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To evaluate the combined use of Lactobacillus salivarius WB21 and (-)-epigallocatechin gallate (EGCg) for oral health maintenance.","subitem_description_type":"Abstract"},{"subitem_description":"The effects of L. salivarius WB21 on growth of Streptococcus mutans, the insoluble glucan produced by S. mutans, and on growth of Porphyromonas gingivalis were evaluated in vitro. In addition, the susceptibility of five oral pathogenic bacteria and L. salivarius WB21 to EGCg, the inhibiting effect of EGCg on methyl mercaptan, and the effects of L. salivarius WB21 and EGCg in combination on growth of P. gingivalis were examined.","subitem_description_type":"Abstract"},{"subitem_description":"Lactobacillus salivarius WB21 showed concentration-dependent inhibition of the growth of S. mutans. Addition of L. salivarius WB21 inhibited production of the insoluble glucan by S. mutans (p < 0.001). A filtrate of L. salivarius WB21 culture solution inhibited growth of P. gingivalis (p < 0.001 vs. control), and this effect was enhanced when it was used in combination with EGCg (p < 0.001 vs. the addition of L. salivarius WB21). In addition, EGCg directly inhibited methyl mercaptan in a concentration-dependent manner (p < 0.001). Concerning bacterial susceptibility to EGCg, growth of P. gingivalis, Prevotella intermedia, and Fusobacterium nucleatum was inhibited at 2.5 mg/mL of EGCg, while that of L. salivarius WB21 was inhibited at 25 mg/mL EGCg.","subitem_description_type":"Abstract"},{"subitem_description":"Our results imply that L. salivarius WB21 may be useful for controlling dental caries, periodontitis, and oral malodor. In addition, the effects of L. salivarius WB21 on periodontitis and oral malodor may be synergistically enhanced by use in combination with EGCg.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第100号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"ScienceDirect"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.archoralbio.2018.11.027","subitem_relation_type_select":"DOI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Higuchi, Takuya"}]},{"creatorNames":[{"creatorName":"Suzuki, Nao"}]},{"creatorNames":[{"creatorName":"Nakaya, Seigo"}]},{"creatorNames":[{"creatorName":"Omagari, Sami"}]},{"creatorNames":[{"creatorName":"Yoneda, Masahiro"}]},{"creatorNames":[{"creatorName":"Hanioka, Takashi"}]},{"creatorNames":[{"creatorName":"Hirofuji, Takao"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-01"}],"displaytype":"detail","filename":"乙第100号_論文(樋口拓哉).pdf","filesize":[{"value":"335.9 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kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"乙第100号_論文審査結果の要旨(樋口拓哉)","url":"https://fdc.repo.nii.ac.jp/record/109/files/乙第100号_論文審査結果の要旨(樋口拓哉).pdf"},"version_id":"10a8fc06-3738-4902-80d2-446b3da48325"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"う蝕"},{"subitem_subject":"エピガロカテキンガラート"},{"subitem_subject":"Lactobacillus salivarius"},{"subitem_subject":"口臭"},{"subitem_subject":"歯周病"},{"subitem_subject":"Antibiosis","subitem_subject_language":"en"},{"subitem_subject":"Catechin","subitem_subject_language":"en"},{"subitem_subject":"Dental Caries","subitem_subject_language":"en"},{"subitem_subject":"Fusobacterium nucleatum","subitem_subject_language":"en"},{"subitem_subject":"Glucans","subitem_subject_language":"en"},{"subitem_subject":"Halitosis","subitem_subject_language":"en"},{"subitem_subject":"Lactobacillus salivarius","subitem_subject_language":"en"},{"subitem_subject":"Microbial Sensitivity Tests","subitem_subject_language":"en"},{"subitem_subject":"Periodontitis","subitem_subject_language":"en"},{"subitem_subject":"Porphyromonas gingivalis","subitem_subject_language":"en"},{"subitem_subject":"Prevotella intermedia","subitem_subject_language":"en"},{"subitem_subject":"Probiotics","subitem_subject_language":"en"},{"subitem_subject":"Streptococcus mutans","subitem_subject_language":"en"},{"subitem_subject":"Tea","subitem_subject_language":"en"},{"subitem_subject":"(-)-Epigallocatechin gallate","subitem_subject_language":"en"},{"subitem_subject":"Oral malodor","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"15","path":["24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-04-01"},"publish_date":"2020-04-01","publish_status":"0","recid":"109","relation_version_is_last":true,"title":["Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-24T02:18:06.258914+00:00"}