{"_buckets": {"deposit": "ea529e88-9c08-42e1-9c67-d5a4bad12587"}, "_deposit": {"created_by": 15, "id": "78", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "78"}, "status": "published"}, "_oai": {"id": "oai:fdc.repo.nii.ac.jp:00000078", "sets": ["19"]}, "author_link": [], "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-10-31"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与大学", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "福岡歯科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "37114"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(歯学)"}]}, "item_10006_description_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "2017年度"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that periodontal pathogen Porphyromonas gingivalis LPS (Pg-LPS) administration lowered the survival rate of diabetic mice. The present study aims to examine the effect of TLR4 blocking on the suppression of Pg-LPS-induced diabetic nephropathy.", "subitem_description_type": "Abstract"}, {"subitem_description": "The survival rate and morphological/biochemical features for streptozotocin-induced diabetic mice with Pg-LPS and TLR4 blocker eritoran administration were investigated by reporter gene assay, urine and blood analysis, immunohistochemistry, and real time-PCR.", "subitem_description_type": "Abstract"}, {"subitem_description": "All of the diabetic mice administered Pg-LPS were euthanized within the survival period of almost all of the diabetic mice. The blood urea nitrogen and creatinine, expression of TLR2 and TGF-b, and type 1 collagen accumulation, in the diabetic mice increased significantly with the Pg-LPS administration. In spite of the limited TLR4 activation with Pg-LPS, the TLR4 blocker eritoran decreased blood urea nitrogen and creatinine, and raised the survival rate of the Pg-LPS-administered diabetic mice slightly. The high expression levels of TLR2, TGF-b, and type 1 collagen in Pg-LPS-administered diabetic mice decreased with eritoran. Nuclear STAT3 which enhances TLR2 expression was detected in the TLR2-expressing glomeruli of diabetic mice. The TLR2 and STAT3 gene expression increased by the Pg-LPS administration but decreased with eritoran. These may suggest that Pg-LPS-induced diabetic nephropathy is mainly dependent on TLR2 signaling on glomerular endothelial cells, and that TLR4 blocker eritoran may play a role to slow the progress of diabetic nephropathy.", "subitem_description_type": "Abstract"}]}, "item_10006_dissertation_number_12": {"attribute_name": "報告番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第289号"}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kajiwara, Koichiro"}]}, {"creatorNames": [{"creatorName": "Takata, Shunsuke"}]}, {"creatorNames": [{"creatorName": "To, Thao T"}]}, {"creatorNames": [{"creatorName": "Takara, Kenyo"}]}, {"creatorNames": [{"creatorName": "Hatakeyama, Yuji"}]}, {"creatorNames": [{"creatorName": "Tamaoki, Sachio"}]}, {"creatorNames": [{"creatorName": "Darveau, Richard Peters"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Hiroyuki"}]}, {"creatorNames": [{"creatorName": "Sawa, Yoshihiko"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-11-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "甲第289号_論文(梶原弘一郎).pdf", "filesize": [{"value": "3.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 3100000.0, "url": {"label": "甲第289号_論文(梶原弘一郎)", "objectType": "fulltext", "url": "https://fdc.repo.nii.ac.jp/record/78/files/甲第289号_論文(梶原弘一郎).pdf"}, "version_id": "fe1002fb-3c67-4127-820d-a2e8dd57349c"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-11-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "甲第289号_要旨(梶原弘一郎).pdf", "filesize": [{"value": "127.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 127700.0, "url": {"label": "要旨", "url": "https://fdc.repo.nii.ac.jp/record/78/files/甲第289号_要旨(梶原弘一郎).pdf"}, "version_id": "2542bab2-7ba7-4b8e-b06a-95461970ba57"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-11-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "甲第289号_論文審査結果の要旨(梶原弘一郎).pdf", "filesize": [{"value": "177.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 177600.0, "url": {"label": "審査結果の要旨", "url": "https://fdc.repo.nii.ac.jp/record/78/files/甲第289号_論文審査結果の要旨(梶原弘一郎).pdf"}, "version_id": "ecd1af75-028f-4c53-9718-9688d60c20d2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "toll-like recepter 2"}, {"subitem_subject": "Porphyromonas gingivalis"}, {"subitem_subject": "LPS"}, {"subitem_subject": "diabetic nephropathy"}, {"subitem_subject": "eritoran"}, {"subitem_subject": "toll-like recepter 2", "subitem_subject_language": "en"}, {"subitem_subject": "Porphyromonas gingivalis", "subitem_subject_language": "en"}, {"subitem_subject": "LPS", "subitem_subject_language": "en"}, {"subitem_subject": "diabetic nephropathy", "subitem_subject_language": "en"}, {"subitem_subject": "eritoran", "subitem_subject_language": "en"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors.", "subitem_title_language": "en"}]}, "item_type_id": "10006", "owner": "15", "path": ["19"], "permalink_uri": "https://fdc.repo.nii.ac.jp/records/78", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-11-16"}, "publish_date": "2017-11-16", "publish_status": "0", "recid": "78", "relation": {}, "relation_version_is_last": true, "title": ["The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors."], "weko_shared_id": -1}
The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors.
https://fdc.repo.nii.ac.jp/records/78
https://fdc.repo.nii.ac.jp/records/78