{"_buckets": {"deposit": "90ff4405-f110-45d4-bcc9-a0ab83e94032"}, "_deposit": {"created_by": 15, "id": "53", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "53"}, "status": "published"}, "_oai": {"id": "oai:fdc.repo.nii.ac.jp:00000053", "sets": ["12"]}, "author_link": [], "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2016-03-12"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与大学", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "福岡歯科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "37114"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(歯学) "}]}, "item_10006_description_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "2015年度"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The ciliary zonule in the eye, also known as Zinn\u0027s zonule, is composed of oxytalan fibers, which are bundles of microfibrils consisting mainly of fibrillin-1. However, it is still unclear which of the microfibril-associated molecules present in the ciliary zonule controls oxytalan fibers. Microfibril-associated glycoprotein-1 (MAGP-1) is the only microfibril-associated molecule identified in the human ciliary zonule. In the present study, we used siRNA against MAGP-1 in cultures of human non-pigmented ciliary epithelial cells to examine the extracellular deposition and appearance of fibrillin-1 employing Western blotting and immunofluorescence. MAGP-1 suppression led to a reduction of fibrillin-1 deposition. Immunofluorescence also confirmed that RNAi-mediated down-regulation of MAGP-1 led to suppression of fiber development. These results suggest that MAGP-1 plays a crucial role in the extracellular deposition of fibrillin-1 during formation of the human ciliary zonule.", "subitem_description_type": "Abstract"}]}, "item_10006_dissertation_number_12": {"attribute_name": "報告番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第271号"}]}, "item_10006_relation_14": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Acta Histochem Cytochem. 2014 Feb 27;47(1):11-7. doi: 10.1267/ahc.13038. 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Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro.
https://fdc.repo.nii.ac.jp/records/53
https://fdc.repo.nii.ac.jp/records/53