{"_buckets": {"deposit": "1feeba93-0f5c-496e-b740-4483a3c7931e"}, "_deposit": {"created_by": 15, "id": "113", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "113"}, "status": "published"}, "_oai": {"id": "oai:fdc.repo.nii.ac.jp:00000113", "sets": ["25"]}, "author_link": [], "item_10006_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2020-03-14"}]}, "item_10006_degree_grantor_9": {"attribute_name": "学位授与大学", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "福岡歯科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "37114"}]}]}, "item_10006_degree_name_8": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(歯学)"}]}, "item_10006_description_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "2019年度"}]}, "item_10006_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Programmed cell death ligands (PD-Ls) are expressed in tumor cells where they bind to programmed cell death-1, an immunocyte co-receptor, resulting in tumor cell evasion from the immune system. Chemotherapeutic drugs have been recently reported to induce the expression of PD-L, such as PD-L1, in some cancer cells. However, little is known regarding PD-L2 expression and its role in oral squamous cell carcinoma (OSCC). In this study, we examined the effect of cisplatin on the expression and regulation of PD-L2 in OSCC cell lines and analyzed malignant behavior in PD-L2-expressing cells using colony, transwell and transformation assays. In addition, we examined PD-L2 expression in the tumor tissues of OSCC patients using cytology and tissue microarray methods. In OSCC cell lines, cisplatin treatment upregulated PD-L2 expression, along with that of the drug efflux transporter ABCG2, via signal transducers and activator of transcription (STAT) 1/3 activation. Moreover, PD-L2-positive or PD-L2-overexpressing cells demonstrated upregulation in both invasion and transformation ability but not in proliferation compared with PD-L2-negative or PD-L2-silencing cells. PD-L2 expression was also observed in OSCC cells of cytology samples and tissue from OSCC patients. The intensity of PD-L2 expression was correlated with more malignant morphological features in the histological appearance and an invasive pattern. Our findings indicate that cisplatin-upregulated PD-L2 expression in OSCC via STAT1/3 activation and the expression of PD-L2 are likely to be associated with malignancy in OSCC. The PD-L2 expression in cisplatin-resistant OSCC cells may be a critical factor in prognosis of advanced OSCC patients.", "subitem_description_type": "Abstract"}]}, "item_10006_dissertation_number_12": {"attribute_name": "報告番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第318号"}]}, "item_10006_relation_15": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Wiley"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/cas.14336", "subitem_relation_type_select": "DOI"}}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sudo, Shunichi"}]}, {"creatorNames": [{"creatorName": "Kajiya, Hiroshi"}]}, {"creatorNames": [{"creatorName": "Okano, Shinji"}]}, {"creatorNames": [{"creatorName": "Sasaki, Mina"}]}, {"creatorNames": [{"creatorName": "Katsumata, Yuri"}]}, {"creatorNames": [{"creatorName": "Ohno, Jun"}]}, {"creatorNames": [{"creatorName": "Ikebe, Tetsuro"}]}, {"creatorNames": [{"creatorName": "Hiraki, Akimitsu"}]}, {"creatorNames": [{"creatorName": "Okabe, Koji"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "甲第318号_論文(首藤俊一).pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": 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"甲第318号_論文審査結果の要旨(首藤俊一).pdf", "filesize": [{"value": "226.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 226100.0, "url": {"label": "甲第318号_論文審査結果の要旨(首藤俊一)", "url": "https://fdc.repo.nii.ac.jp/record/113/files/甲第318号_論文審査結果の要旨(首藤俊一).pdf"}, "version_id": "bb2a1259-f737-4f6e-8341-cd3b466b96f1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "cisplatin"}, {"subitem_subject": "metastasis"}, {"subitem_subject": "oral squamous cell carcinoma"}, {"subitem_subject": "programmed cell death ligand 2"}, {"subitem_subject": "signal transducers and activator of transcription 1/3"}, {"subitem_subject": "cisplatin", "subitem_subject_language": "en"}, {"subitem_subject": "metastasis", "subitem_subject_language": "en"}, {"subitem_subject": "oral squamous cell carcinoma", "subitem_subject_language": "en"}, {"subitem_subject": "programmed cell death ligand 2", "subitem_subject_language": "en"}, {"subitem_subject": "signal transducers and activator of transcription 1/3", "subitem_subject_language": "en"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma.", "subitem_title_language": "en"}]}, "item_type_id": "10006", "owner": "15", "path": ["25"], "permalink_uri": "https://fdc.repo.nii.ac.jp/records/113", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-03-25"}, "publish_date": "2020-03-25", "publish_status": "0", "recid": "113", "relation": {}, "relation_version_is_last": true, "title": ["Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma."], "weko_shared_id": -1}
Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma.
https://fdc.repo.nii.ac.jp/records/113
https://fdc.repo.nii.ac.jp/records/113