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During development, microfibrils act as a template on which tropoelastin is deposited. Fibrillin-1 is the major component of microfibrils. It is not clear whether elastic fiber-associated molecules, such as fibulins, contribute to tropoelastin deposition. Among the fibulin family, fibulin-2, -4 and -5 are capable of binding to tropoelastin and fibrillin-1. In the present study, we used the RNA interference (RNAi) technique to establish individual gene-specific knockdown of fibulin-2, -4 and -5 in elastin-producing cells (human gingival fibroblasts; HGF). We then examined the extracellular deposition of tropoelastin using immunofluorescence. RNAi-mediated down-regulation of fibulin-4 and -5 was responsible for the diminution of tropoelastin deposition. Suppression of fibulin-5 appeared to inhibit the formation of fibrillin-1 microfibrils, while that of fibulin-4 did not. Similar results to those for HGF were obtained with human dermal fibroblasts. These results suggest that fibulin-4 and -5 may be associated in different ways with the extracellular deposition of tropoelastin during elastic fiber formation in elastin-producing cells in culture.", "subitem_description_type": "Abstract"}]}, "item_10006_dissertation_number_12": {"attribute_name": "報告番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第254号"}]}, "item_10006_relation_14": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Acta Histochem Cytochem. 2010 Dec 29;43(6):131-8. doi: 10.1267/ahc.10026. Epub 2010 Nov 20."}]}]}, "item_10006_relation_15": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "J-STAGE"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.jstage.jst.go.jp/article/ahc/43/6/43_10026/_article", "subitem_relation_type_select": "URI"}}]}, "item_10006_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "著作権は日本組織細胞化学会が所有"}]}, "item_10006_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamauchi, Yoshinori"}]}, {"creatorNames": [{"creatorName": "Tsuruga, Eichi"}]}, {"creatorNames": [{"creatorName": "Nakashima, Kazuki"}]}, {"creatorNames": [{"creatorName": "Sawa, Yoshihiko"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Hiroyuki"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2014-04-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "甲第254号_論文(山内).pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "著作権は日本組織細胞化学会が所有", "licensetype": "license_note", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "甲第254号_論文(山内)", "objectType": "fulltext", "url": "https://fdc.repo.nii.ac.jp/record/10/files/甲第254号_論文(山内).pdf"}, "version_id": "e92bcadf-2394-413d-8e2f-e39ea58695cf"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2014-04-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "甲第254号_論文内容の要旨(山内).pdf", "filesize": [{"value": "71.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 71500.0, "url": {"label": "要旨", "url": "https://fdc.repo.nii.ac.jp/record/10/files/甲第254号_論文内容の要旨(山内).pdf"}, "version_id": "c9b62e15-0f6d-48f0-95b1-30d06ecfaf76"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2014-04-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "甲第254号_論文審査結果の要旨(山内).pdf", "filesize": [{"value": "263.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 263000.0, "url": {"label": "審査結果の要旨", "url": "https://fdc.repo.nii.ac.jp/record/10/files/甲第254号_論文審査結果の要旨(山内).pdf"}, "version_id": "36c439c2-8363-4878-8f14-8ff1e8577b06"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "トロポエラスチン"}, {"subitem_subject": "Fibulin-4"}, {"subitem_subject": "歯肉線維芽細胞"}, {"subitem_subject": "弾性線維"}, {"subitem_subject": "tropoelastin", "subitem_subject_language": "en"}, {"subitem_subject": "Fibulin-4", "subitem_subject_language": "en"}, {"subitem_subject": "human gingival fibroblasts", "subitem_subject_language": "en"}, {"subitem_subject": "elastic fiber", "subitem_subject_language": "en"}, {"subitem_subject": "Fibulin", "subitem_subject_language": "en"}, {"subitem_subject": "elastic fiber", "subitem_subject_language": "en"}, {"subitem_subject": "fibrillin", "subitem_subject_language": "en"}, {"subitem_subject": "microfibrils", "subitem_subject_language": "en"}, {"subitem_subject": "tropoelastin", "subitem_subject_language": "en"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture.", "subitem_title_language": "en"}]}, "item_type_id": "10006", "owner": "15", "path": ["6"], "permalink_uri": "https://fdc.repo.nii.ac.jp/records/10", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-04-28"}, "publish_date": "2014-04-28", "publish_status": "0", "recid": "10", "relation": {}, "relation_version_is_last": true, "title": ["Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture."], "weko_shared_id": -1}
Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture.
https://fdc.repo.nii.ac.jp/records/10
https://fdc.repo.nii.ac.jp/records/10