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Permalink : http://id.nii.ac.jp/1167/00000075/
Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis
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| 甲第298号_論文(田﨑園子) |
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甲第298号_論文(田﨑園子)
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| 甲第298号_論文内容の要旨(田﨑園子) |
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甲第298号_論文内容の要旨(田﨑園子)
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| 甲第298号_論文審査結果の要旨(田﨑園子) |
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甲第298号_論文審査結果の要旨(田﨑園子)
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| アイテムタイプ | 学位論文 / Thesis or Dissertation |
|---|---|
| 言語 | 英語 |
| キーワード |
Candida albicans, mycelial membranes, Th17, oral candidiasis, adoptive transfer |
| 著者 |
Sonoko Tasaki
Tamaki Cho Jun-ichi Nagao Shojiro Ikezaki Yuka Narita Ken-ichi Arita-Morioka Kanae Yasumatsu Keita Toyoda Hiroshi Kojima Yoshihiko Tanaka |
| 抄録 |
Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step.
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| 学位名 |
博士（歯学）
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| 学位授与大学 |
福岡歯科大学
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| 学位授与年度 |
2017年度
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| 学位授与年月日 |
2018-03-29
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| 報告番号 |
37114甲第298号
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| 関連サイト |
OXFORD
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| 著者版フラグ | ETD |
