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Permalink : http://id.nii.ac.jp/1167/00000067/
The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis.
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甲第297号_論文(緒方)
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甲第297号_論文内容の要旨(緒方)
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| アイテムタイプ | 学位論文 / Thesis or Dissertation |
|---|---|
| 言語 | 英語 |
| キーワード |
エナメル質, 石灰化, TRPM7, キナーゼ, イオンチャネル |
| 著者 |
Ogata Kayoko
Tsumuraya Tomoyuki Oka Kyoko Shin Masashi Okamoto Fujio Kajiya Hiroshi Katagiri Chiaki Ozaki Masao Matsushita Masayuki Okabe Koji |
| 抄録 |
Transient receptor potential melastatin-7 (TRPM7) is a bi-functional protein containing a kinase domain fused to an ion channel. TRPM7 is highly expressed in ameloblasts during tooth development. Here we show that TRPM7 kinase-inactive knock-in mutant mice (TRPM7 KR mice) exhibited small enamel volume with opaque white-colored incisors. The TRPM7 channel function of ameloblast-lineage cells from TRPM7 KR mice was normal. Interestingly, phosphorylation of intracellular molecules including Smad1/5/9, p38 and cAMP response element binding protein (CREB) was inhibited in ameloblasts from TRPM7 KR mice at the pre-secretory stage. An immunoprecipitation assay showed that CREB was bound to TRPM7, suggesting that direct phosphorylation of CREB by TRPM7 was inhibited in ameloblast-lineage cells from TRPM7 KR mice. These results indicate that the function of the TRPM7 kinase domain plays an important role in ameloblast differentiation, independent of TRPM7 channel activity, via phosphorylation of CREB.
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| 学位名 |
博士（歯学）
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| 学位授与大学 |
福岡歯科大学
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| 学位授与年度 |
2017年度
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| 学位授与年月日 |
2018-03-29
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| 報告番号 |
37114甲第297号
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| 関連サイト |
Scientific Reports
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| 著者版フラグ | ETD |
